Deficiency of histone variant macroH2A1.1 is associated with sexually dimorphic obesity in mice
Valentina Chiodi,
Francesca Rappa,
Oriana Lo Re
et al.
Abstract:Obesity has a major socio-economic health impact. There are profound sex differences in adipose tissue deposition and obesity-related conditions. The underlying mechanisms driving sexual dimorphism in obesity and its associated metabolic disorders remain unclear. Histone variant macroH2A1.1 is a candidate epigenetic mechanism linking environmental and dietary factors to obesity. Here, we used a mouse model genetically depleted of macroH2A1.1 to investigate its potential epigenetic role in sex dimorphic obesity… Show more
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