Deficiency of circulating progenitor cells associated with vascular thrombosis of hemodialysis patients

Hsieh, Mu-Yang; Chen, Tsung Yan; Lin, Lin; Chuang, Shao Yuan; Lin, Shing Jong; Tarng, Der Cheng; Huang, Po Hsun; Wu, Chih‐Cheng

doi:10.1093/ndt/gfw401

Cited by 8 publications

(2 citation statements)

References 27 publications

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“…Previous studies demonstrated that EPC was associated with intimal hyperplasia after balloon angioplasty, both in arteries and dialysis accesses 35,36 . The association of EPC with late thrombosis may be mediated through its suppressive effect on intimal hyperplasia, or just via its role as a summative marker of vascular health 37 .…”

Section: Discussionmentioning

confidence: 99%

Temporal distribution and biological determinants of thrombotic events after interventions for dialysis vascular access

Hsieh

Lee

et al. 2019

Sci Rep

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Endovascular therapy is the principal therapy for haemodialysis vascular access dysfunction. Nonetheless, the incidence and determinants of post-intervention thrombotic events are unclear. This prospective cohort study evaluated the incidence and timing of thrombotic events after endovascular therapy and analysed the clinical, angiographic, and biological determinants of thrombosis. Of the 236 patients enrolled, 91 experienced post-intervention thrombotic events within 1 year. The 1-year thrombosis-free patency was 28% for thrombosed accesses, 53% for non-thrombosed grafts, and 78% for non-thrombosed fistulas. Forty-one of the 91 thrombotic events (45%) occurred within 3 months post-intervention. In the univariate analysis, early thrombosis was associated with longer haemodialysis duration (hazard ratio [HR], 1.01; 95% confidence interval [CI], 1.01–1.02), graft access (HR, 7.69; 95% CI, 3.33–20.0), multiple stenoses (HR, 2.69; 95% CI, 1.36–5.37), and high indoxyl sulphate (IS) levels (HR, 1.55; 95% CI, 1.32–1.82). Late thrombosis was associated with diabetes (HR, 1.89; 95% CI, 1.01–3.57), cardiovascular disease (HR, 2.38; 95% CI, 1.27–4.54), and endothelial progenitor cell counts (HR, 0.97; 95% CI, 0.93–0.99). After multivariate adjustment, high IS was the major predisposing factor for early post-intervention thrombosis (HR, 1.41; 95% CI, 1.18–1.69). Our findings suggest that measures to decrease IS could target the most critical period of thrombosis.

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Section: Discussionmentioning

confidence: 99%

Temporal distribution and biological determinants of thrombotic events after interventions for dialysis vascular access

Hsieh

Lee

et al. 2019

Sci Rep

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“…Decreased EPC counts have also been found to be associated with early and frequent restenosis of dialysis vascular accesses after percutaneous angioplasty [47]. In a 3-year prospective study by Hsiesh et al [48], decreased circulating EPC counts (defined as CD34+KDR+ cells) were significantly associated with systemic vascular thrombosis and vascular access thrombosis.…”

Section: Epc Studies In Various Disease Modelsmentioning

confidence: 99%

Endothelial Progenitor Cells and Kidney Diseases

Özkök

Yildiz

2018

Kidney Blood Press Res

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Endothelial progenitor cells (EPC) are bone marrow derived or tissue-resident cells that play major roles in the maintenance of vascular integrity and repair of endothelial damage. Although EPCs may be capable of directly engrafting and regenerating the endothelium, the most important effects of EPCs seem to be depended on paracrine effects. In recent studies, specific microvesicles and mRNAs have been found to mediate the pro-angiogenic and regenerative effects of EPCs on endothelium. EPC counts have important prognostic implications in cardiovascular diseases (CVD). Uremia and inflammation are associated with lower EPC counts which probably contribute to increased CVD risks in patients with chronic kidney disease. Beneficial effects of the EPC therapies have been shown in studies performed on different models of CVD and kidney diseases such as acute and chronic kidney diseases and glomerulonephritis. However, lack of a clear definition and specific marker of EPCs is the most important problem causing difficulties in interpretation of the results of the studies investigating EPCs.

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Thrombophilia Associated with Early Post-angioplasty Thrombosis of Dialysis Vascular Access

Chen

Lin

Hsieh

et al. 2018

Cardiovasc Intervent Radiol

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Deficiency of circulating progenitor cells associated with vascular thrombosis of hemodialysis patients

Abstract: Our study of a population of HD patients showed that a low level of circulating EPCs is associated with thrombosis.

Cited by 8 publications

References 27 publications

Temporal distribution and biological determinants of thrombotic events after interventions for dialysis vascular access

Temporal distribution and biological determinants of thrombotic events after interventions for dialysis vascular access

Endothelial Progenitor Cells and Kidney Diseases

Thrombophilia Associated with Early Post-angioplasty Thrombosis of Dialysis Vascular Access

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