Deficiency of 25-Hydroxyvitamin D and Dyslipidemia in Indian Subjects

Abstract

Background. Vitamin D deficiency is widespread throughout the world. Several reports have incriminated vitamin D deficiency as the cause of rickets, osteomalacia, and other chronic diseases. Recent studies have suggested a possible link between deficiency of 25-hydroxyvitamin D and dyslipidemia. Aim. To investigate the association between 25-hydroxyvitamin D deficiency and dyslipidemia in Indian subjects. Methodology. We recruited 150 asymptomatic consecutive subjects from patients' attendees at the Departments of Neurology and Medicine in Yashoda Hospital, Hyderabad, India. Study period was from October 2011 to March 2012. All subjects underwent 25-hydroxyvitamin D assay by chemiluminescent microparticle immunoassay, fasting blood sugar and lipid profile, calcium, phosphorus, alkaline phosphatase, and C-reactive protein (CRP). Results. Out of 150 subjects, men were 82 (54.6%), and mean age was 49.4 (±15.6) years. Among risk factors, hypertension was noted in 63/150 (42%), 25-hydroxyvitamin D deficiency in 59/150 (39.3%), diabetes in 45/150 (30%), dyslipidemia in 60 (40%), smoking in 35/150 (23.3%), and alcoholism in 27/150 (18%). Deficiency of 25-hydroxyvitamin D was significantly associated with dyslipidemia (P = 0.0001), mean serum glucose (P = 0.0002) mean CRP (P = 0.04), and mean alkaline phosphatase (P = 0.01). Multivariate analysis showed that 25-hydroxyvitamin D deficiency was independently associated with dyslipidemia (odds ratio: 1.9; 95% CI : 1.1–3.5). Conclusions. We found that deficiency of 25-hydroxyvitamin D was independently associated with dyslipidemia in Indian subjects.

Relation of serum 25(OH) D with variables of thyroid and lipid profile in perimenopausal women

“…An Indian population based study concluded this significant association with dyslipidemia after observing a positive correlation with HDL and negative correlation with remaining fractions of lipid profile. 27 Deficiency of vitamin D may initiate the elevation of lipolysis circulating free fatty acids and increase hepatic synthesis of LDL cholesterol. Furthermore, in support of these findings, a study based on premenopausal women concluded even after considering lifestyle factors serum 25(OH) D was negatively associated with TC, TG and LDL-C and positive association with HDL-C. 28 …”

Vitamin D: Panacea unexplored

“…High serum vitamin D levels are associated with a favorable lipid profile 24 and low serum vitamin D levels have been associated with dyslipidamia including elevated LDL cholesterol and low HDL-C levels in Indian participants. 25 The postulated mechanisms include vitamin D-mediated calcium absorption reducing hepatic triglyceride formation and secretion, regulation of VLDL cholesterol receptor expression, increased peripheral removal of triglycerides and reduction of VLDL cholesterol and triglycerides secondary to reducing insulin resistance. 25 …”

Assessment of Vitamin D and its Correlation with Lipid Markers among Adult Female during the Course of Pregnancy in and Around Dhanbad, Jharkhand

“…It is prevalent in various parts of the world including India with an increased occurrence in high and low latitude countries. 9 In recent years the prevalence of vitamin D deficiency has increased. There is a high prevalence of vitamin D deficiency in pregnant women from nonwestern countries residing in northern Europe, indeed vitamin D deficiency during pregnancy is an ongoing epidemic.…”