Deficiency in ethanolamine plasmalogen leads to altered cholesterol transport

Munn, Natalie J.; Arnio, Emily; Liu, Dailan; Zoeller, Raphael A.; Liscum, Laura

doi:10.1194/jlr.m200363-jlr200

Cited by 100 publications

(77 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, phospholipids have also been suggested to play important roles in HDL-mediated RCT (39)(40)(41)(42). Interestingly, Pls-defi cient cells have been shown to exhibit reduced cholesterol effl ux by HDL ( 43 ), which may be associated with impaired cellular processing of cholesterol ( 44,45 ). These notions suggest the relevance of serum Pls to the physiologically important functions of HDL, including RCT.…”

Section: Discussionmentioning

confidence: 96%

Serum choline plasmalogens, particularly those with oleic acid in sn-2, are associated with proatherogenic state

Nishimukai

Maeba

Yamazaki³

et al. 2014

Journal of Lipid Research

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 96%

Serum choline plasmalogens, particularly those with oleic acid in sn-2, are associated with proatherogenic state

Nishimukai

Maeba

Yamazaki³

et al. 2014

Journal of Lipid Research

View full text Add to dashboard Cite

“…Recent studies in vitro demonstrated the ability of PE pl to protect cholesterol-rich membranes from oxidative stress (102). Furthermore, deficiency in PE pl could lead to altered cholesterol transport (103).…”

Section: Admentioning

confidence: 99%

Phospholipase A2 in the central nervous system

Sun

Xu²,

Jensen

et al. 2004

Journal of Lipid Research

355

View full text Add to dashboard Cite

Phospholipase A 2 (PLA 2 ) belongs to a family of enzymes that catalyze the cleavage of fatty acids from the sn-2 position of phospholipids. There are more than 19 different isoforms of PLA 2 in the mammalian system, but recent studies have focused on three major groups, namely, the group IV cytosolic PLA 2 , the group II secretory PLA 2 (sPLA 2 ), and the group VI Ca 2 ؉ -independent PLA 2 . These PLA 2 s are involved in a complex network of signaling pathways that link receptor agonists, oxidative agents, and proinflammatory cytokines to the release of arachidonic acid (AA) and the synthesis of eicosanoids. PLA 2 s acting on membrane phospholipids have been implicated in intracellular membrane trafficking, differentiation, proliferation, and apoptotic processes. All major groups of PLA 2 are present in the central nervous system (CNS). Therefore, this review is focused on PLA 2 and AA release in neural cells, especially in astrocytes and neurons. In addition, because many neurodegenerative diseases are associated with increased oxidative and inflammatory responses, an attempt was made to include studies on PLA 2 in cerebral ischemia, Alzheimer's disease, and neuronal injury due to excitotoxic agents. Information from these studies has provided clear evidence for the important role of PLA 2 in regulating physiological and pathological functions in the CNS. Bazan (1) recognized the important role of arachidonic acid (AA) in the central nervous system (CNS) in the '70s when he observed the rapid and transient release of this fatty acid in the brain due to seizure and cerebral ischemia. The "Bazan effect" has since stimulated over 30 years of investigations attempting to unravel mechanisms regulating AA release from membrane phospholipids in the CNS.Phospholipids in CNS membranes are enriched in polyunsaturated fatty acids (PUFAs) (2). Metabolism of PUFA is stringently controlled by phospholipase A 2 (PLA 2 ) and acyltransferases-known as the "deacylation-reacylation cycle" (3-5). Under normal conditions, free fatty acids (FFAs) released by PLA 2 are rapidly taken up by membrane phospholipids through an energy-dependent process involving CoA and ATP (6). To date, limited information is available on the structure and functions of acyltransferases. However, recent advances in molecular biological techniques have aided in the identification of many genes encoding different groups of PLA 2 and have provided new information on the properties and functions of these molecules.PLA 2 (EC3.1.1.4.) belongs to a family of enzymes that catalyze the cleavage of fatty acids from the sn -2 position of phospholipids. These enzymes are not only important for maintenance of cell membrane phospholipids; they also play a key role in regulating the release of AA, a precursor for synthesis of eicosanoids. In the mammalian system, more than 19 different isoforms of PLA 2 have been identified, and different PLA 2 s have been shown to participate in physiological events related to cell injury, inflammation, and apoptosis (7,8). Re...

show abstract

“…Patients with rhizomelic chondrodysplasia punctata manifest clinical features of shortened proximal long bones, rhizomelia, bilateral congenital cataracts, and mental and growth retardation (2), predicting a role of plasmalogens in the development of bone, brain, and eye lens. In addition, studies using plasmalogen-defective mutant Chinese hamster ovary (CHO) cells revealed that plasmalogens are important for the esterification of cholesterol (3). Abnormality of other processes including myelination, paranode organization, and purkinje cell innervation is shown in a knock-out mouse defective in dihydroxyacetone phosphate acyltransferase, an essential enzyme for the synthesis of plasmalogens (4).…”

mentioning

confidence: 99%

Dysregulation of Plasmalogen Homeostasis Impairs Cholesterol Biosynthesis

Honsho

Abe

Fujiki

2015

Journal of Biological Chemistry

View full text Add to dashboard Cite

Background: Physiological significance of plasmalogen homeostasis remains unknown. Results: Elevation of plasmalogens reduced cholesterol synthesis by enhancing degradation of squalene monooxygenase (SQLE), whereas SQLE was stabilized in the absence of plasmalogens. Conclusion: Plasmalogens regulate cholesterol synthesis by modulating the stability of SQLE. Significance: SQLE stability is modulated in response to the cellular level of plasmalogens, in addition to the acute changes of cholesterol level.

show abstract

Deficiency in ethanolamine plasmalogen leads to altered cholesterol transport

Cited by 100 publications

References 45 publications

Serum choline plasmalogens, particularly those with oleic acid in sn-2, are associated with proatherogenic state

Serum choline plasmalogens, particularly those with oleic acid in sn-2, are associated with proatherogenic state

Phospholipase A2 in the central nervous system

Dysregulation of Plasmalogen Homeostasis Impairs Cholesterol Biosynthesis

Contact Info

Product

Resources

About