Defibrotide for Prevention and Treatment of Veno-Occlusive Disease in Adults: Single-Center Experience

Abstract

Background: Hepatic veno-occlusive disease (VOD) has been reported at a rate up to 50% following intensive conditioning regimens used in allogeneic hematopoietic stem cell transplantation (AHSCT). Studies on the prophylactic effect of defibrotide to prevent hepatic VOD in adults are rare.