Deferasirox alleviates DSS-induced ulcerative colitis in mice by inhibiting ferroptosis and improving intestinal microbiota

Wu, Yi; Ran, Lei; Yang, Yue; Gao, Xianling; Peng, Man; Liu, Sida; Sun, Le; Wan, Jia; Wang, Yu; Yang, Kun; Yin, Min; Chunyu, Wei-Xun

doi:10.1016/j.lfs.2022.121312

Cited by 69 publications

(39 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, the expressions of FTH in the colon tissues of experimental colitis mice remain controversial. Some studies have confirmed an increase of FTH expressions in the colitis mice, while decreased FTH expressions are observed in other literatures (Chen et al, 2020;Xu et al, 2020;Xu et al, 2021;Wu et al, 2023). In this study, FTH levels were downregulated in the colon tissues of the colitis rats, which were reversed by XJS.…”

Section: Discussionsupporting

confidence: 86%

Xue-Jie-San restricts ferroptosis in Crohn’s disease via inhibiting FGL1/NF-κB/STAT3 positive feedback loop

Gao

Zhang

et al. 2023

Front. Pharmacol.

View full text Add to dashboard Cite

Crohn’s disease (CD) is an incurable inflammatory bowel disease due to unclear etiology and pathogenesis. Accumulating evidences have shown the harmful role of ferroptosis in CD onset and development. Additionally, fibrinogen-like protein 1 (FGL1) has been verified to be a potential therapeutic target of CD. Xue-Jie-San (XJS) is an effective prescription for treating CD. However, its therapeutic mechanism has not been fully elucidated. This study aimed to determine whether XJS alleviating CD via regulating ferroptosis and FGL1 expression. A colitis rat model was induced by 2,4,6-trinitrobenzene sulfonic acid and treated with XJS. The disease activity indices of the colitis rats were scored. Histopathological damage was assessed using HE staining. ELISA was performed to examine inflammatory cytokines. Transmission electron microscopy was utilized to observe ultrastructure changes in intestinal epithelial cells (IECs). Iron load was evaluated by examining iron concentrations, the expressions of FPN, FTH and FTL. Lipid peroxidation was investigated through detecting the levels of ROS, 4-HNE, MDA and PTGS2. Furthermore, the SLC7A11/GSH/GPX4 antioxidant system and FGL1/NF-κB/STAT3 signaling pathway were examined. The results showed that colitis was dramatically ameliorated in the XJS-treated rats as evidenced by relief of clinical symptoms and histopathological damages, downregulation of pro-inflammatory cytokines IL-6, IL-17 and TNF-α, and upregulation of anti-inflammatory cytokine IL-10. Furthermore, XJS administration led to ferroptosis inhibition in IECs by reducing iron overload and lipid peroxidation. Mechanistically, XJS enhanced the SLC7A11/GSH/GPX4 antioxidant system negatively regulated by the FGL1/NF-κB/STAT3 positive feedback loop. In conclusion, XJS might restrain ferroptosis in IECs to ameliorate experimental colitis by inhibition of FGL1/NF-κB/STAT3 positive feedback loop.

show abstract

Section: Discussionsupporting

confidence: 86%

Xue-Jie-San restricts ferroptosis in Crohn’s disease via inhibiting FGL1/NF-κB/STAT3 positive feedback loop

Gao

Zhang

et al. 2023

Front. Pharmacol.

View full text Add to dashboard Cite

show abstract

“…Previous studies reported that the relative abundance of Romboutsia and Streptococcus was increased by the DSS treatment but decreased by an anti-colitis drug, which was similar to our results. 46,49,50 The role of Dubosiella in colitis was controversial 46 but it has been observed to enrich in the DSS group and has a positive correlation with intestinal inflammation in this study. Conversely, Blautia , Bifdobacterium , Faecalibaculum exhibited a positive correlation with these anti-inflammation-associated indicators, but a negative correlation with these pro-inflammation-related indicators.…”

Section: Resultsmentioning

confidence: 58%

Role of extracted phytochemicals from Rosa sterilis S. D. Shi in DSS-induced colitis mice: potential amelioration of UC

Luan,

Pan,

Chen

et al. 2023

Food Funct.

View full text Add to dashboard Cite

show abstract

“…S8‡). 36 The levels of Lactobacillus , Burkholderiales , and Vicinamibacteraceae increased in the combined treatment group compared with anti-PD-1 administration alone (Fig. 5d).…”

Section: Resultsmentioning

confidence: 92%

Dietary Lactobacillus rhamnosus GG extracellular vesicles enhance antiprogrammed cell death 1 (anti-PD-1) immunotherapy efficacy against colorectal cancer

Lu,

Xu,

Zhao

et al. 2023

Food Funct.

View full text Add to dashboard Cite

show abstract

Deferasirox alleviates DSS-induced ulcerative colitis in mice by inhibiting ferroptosis and improving intestinal microbiota

Cited by 69 publications

References 67 publications

Xue-Jie-San restricts ferroptosis in Crohn’s disease via inhibiting FGL1/NF-κB/STAT3 positive feedback loop

Xue-Jie-San restricts ferroptosis in Crohn’s disease via inhibiting FGL1/NF-κB/STAT3 positive feedback loop

Role of extracted phytochemicals from Rosa sterilis S. D. Shi in DSS-induced colitis mice: potential amelioration of UC

Dietary Lactobacillus rhamnosus GG extracellular vesicles enhance antiprogrammed cell death 1 (anti-PD-1) immunotherapy efficacy against colorectal cancer

Contact Info

Product

Resources

About