Defensive behaviors in wild and laboratory (Swiss) mice: the mouse defense test battery

Rj, Blanchard; Ma, Hebert; Pf, Ferrari; Palanza, Paola; Figueira, Rayson; Dc, Blanchard; Parmigiani, Stefano

doi:10.1016/s0031-9384(98)00012-2

Cited by 140 publications

(98 citation statements)

References 21 publications

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“…Blanchard et al [32] have recently reported that wild mice (from the same stock as that used in the present study) exhibit markedly higher levels of flight behavior and escape attempts in response to an approaching rat predator than do Swiss (CD-1) mice. As an overwhelming urge to escape from an environment or situation can be an important feature of panic disorder [65], these authors have proposed that the flight/escape responses shown by mice in threatening contexts may be analogous to the behavioral symptoms of panic.…”

Section: Discussionmentioning

confidence: 52%

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Behavioral profile of wild mice in the elevated plus-maze test for anxiety

Holmes

Parmigiani

Ferrari

et al. 2000

Physiology & Behavior

126

104

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Section: Discussionmentioning

confidence: 52%

“…Thus, despite remarkable similarities in social, aggressive, and predatory behavior (e.g., Refs. [28 ± 31]), antipredator flight responses in Swiss CD-1 laboratory mice are significantly less intense than those exhibited by the wild house mouse (Mus musculus) [32].…”

Section: Introductionmentioning

confidence: 99%

Behavioral profile of wild mice in the elevated plus-maze test for anxiety

Holmes

Parmigiani

Ferrari

et al. 2000

Physiology & Behavior

126

104

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“…Importantly, wild-backcrossed females also manifested all behavioural traits that had been lost through domestication in laboratory females, including aggressive behaviour toward alien adults and newborn pups. These latter sets of behaviours are considered to be male-typical traits that are rarely exhibited by laboratory females 26,[34][35][36] , whereas in nature they serve evolutionary adaptive purposes 26,37 and are robustly exhibited in both wild males and females, thus offering an unique opportunity for mechanistic investigation in both sexes.…”

Section: Discussionmentioning

confidence: 99%

“…Pups that were attacked during the experiment were immediately removed from the cage and humanely euthanized. Resident-intruder assay (same-sex adult interactions) 15 . An alien mouse, matched for age, sex and strain, was introduced into the home cage of the tested adult mouse for 15 min.…”

Section: Methodsmentioning

confidence: 99%

“…In addition, most laboratory mouse strains are the product of decades of artificial selection, both deliberate and inadvertent, that selected specific traits promoting reproductive success under laboratory conditions. For example, deliberate human selection interfered with locomotion, as well as with social and reproductive traits such as biting, aggressive conspecific competition, avoidance of mating with close relatives and fleeing/ freezing predatory responses, that had evolved to maximize fitness in the natural environment 10,[13][14][15][16] . Furthermore, captive mice in standard laboratory conditions are deprived of normal social context and lack social/reproductive pressures.…”

mentioning

confidence: 99%

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Mapping ecologically relevant social behaviours by gene knockout in wild mice

et al. 2014

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The laboratory mouse serves as an important model system for studying gene, brain and behavioural interactions. Powerful methods of gene targeting have helped to decipher gene-function associations in human diseases. Yet, the laboratory mouse, obtained after decades of human-driven artificial selection, inbreeding, and adaptation to captivity, is of limited use for the study of fitness-driven behavioural responses that characterize the ancestral wild house mouse. Here, we demonstrate that the backcrossing of wild mice with knockout mutant laboratory mice retrieves behavioural traits exhibited exclusively by the wild house mouse, thereby unmasking gene functions inaccessible in the domesticated mutant model. Furthermore, we show that domestication had a much greater impact on females than on males, erasing many behavioural traits of the ancestral wild female. Hence, compared with laboratory mice, wild-derived mutant mice constitute an improved model system to gain insights into neuronal mechanisms underlying normal and pathological sexually dimorphic social behaviours.

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Accelerated nervous system development contributes to behavioral efficiency in the laboratory mouse: A behavioral review and theoretical proposal

Whishaw

Metz

Kolb

et al. 2001

Developmental Psychobiology

103

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The emergence of the laboratory mouse as a favored species for genetic research has posed a number of problems for scientists interested in the reflection of genetic influences in mouse behavior. It is commonly thought that rat behavior, which has been studied more extensively than mouse behavior, could be easily generalized to mice. In this article, a number of categories of behavior displayed by the mouse (motor, spatial, defensive, social) are reviewed and contrasted with the same categories of behavior displayed by the rat. The comparison suggests that mouse behavior is simpler and more dependent upon elementary actions than the behavior of the rat. We suggest that the behavioral simplification in the mouse adapts it for a different ecological niche than that occupied by the rat. We propose that this simplification may be mediated by accelerated brain maturation during development. We further propose that this developmental acceleration in the mouse renders it less dependent upon complex social behavior and plastic nervous system changes associated with learning than the rat. This difference poses problems for the development of relevant methods of behavioral analysis and interpretation. Since the mouse's biological adaptations will be reflected in laboratory behavior, suggestions are made for behavioral approaches to the study and interpretation of mouse behavior.

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Defensive behaviors in wild and laboratory (Swiss) mice: the mouse defense test battery

Cited by 140 publications

References 21 publications

Behavioral profile of wild mice in the elevated plus-maze test for anxiety

Behavioral profile of wild mice in the elevated plus-maze test for anxiety

Mapping ecologically relevant social behaviours by gene knockout in wild mice

Accelerated nervous system development contributes to behavioral efficiency in the laboratory mouse: A behavioral review and theoretical proposal

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