Defensive Antibacterial Coating (DAC®) for prevention of infection in ACL reconstruction: a feasibility study

Aicale, Rocco; Oliva, Francesco; Maffulli, Nicola; Maff, N.

doi:10.32098/mltj.01.2020.22

Cited by 10 publications

(7 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is a renewed interest in the prevention of infection in ligament reconstruction surgery. It is possible that devices developed for intra-articular ligament reconstruction procedures may well be used in MPFL reconstruction, especially when employing allografts [ 2 ]. Surgeons must be aware of the storage processes, sterilization methods, and standards of the tissue bank they use.…”

Section: Discussionmentioning

confidence: 99%

Comparable outcome for autografts and allografts in primary medial patellofemoral ligament reconstruction for patellofemoral instability: systematic review and meta-analysis

Migliorini

Trivellas

Eschweiler

et al. 2021

Knee Surg Sports Traumatol Arthrosc

View full text Add to dashboard Cite

Purpose This study updates the current evidence on the role of allografts versus autografts for medial patellofemoral ligament (MPFL) reconstruction in patients with patellofemoral instability. Methods The study was performed according to the PRISMA guidelines. In March 2021, a literature search in the main online databases was performed. Studies reporting quantitative data concerning primary MPFL reconstruction using an allograft were considered for inclusion. The Coleman Methodology Score was used to assess the methodological quality of the selected articles. Results Data from 12 studies (474 procedures) were retrieved. The mean follow-up was 42.2 (15–78.5) months. The mean age was 21.1 ± 6.2 years. 64.9% (285 of 439) of patients were female. At the last follow-up, the Tegner (p < 0.0001), Kujala (p = 0.002) and the Lysholm (p < 0.0001) scores were minimally greater in the autografts. The similarity was found in the rate of persistent instability sensation and revision. The allograft group evidenced a lower rate of re-dislocations (p = 0.003). Conclusion Allografts may represent a feasible alternative to traditional autograft for MPFL reconstruction in selected patients with patellofemoral instability. Allograft tendons yielded similar PROMs, rates of persistent instability, and revision. Allograft reconstructions tended to have modestly lower re-dislocation rates. Level of evidence IV.

show abstract

Section: Discussionmentioning

confidence: 99%

Comparable outcome for autografts and allografts in primary medial patellofemoral ligament reconstruction for patellofemoral instability: systematic review and meta-analysis

Migliorini

Trivellas

Eschweiler

et al. 2021

Knee Surg Sports Traumatol Arthrosc

View full text Add to dashboard Cite

show abstract

“…Considering the clinical applications, our injectable systems could adjust paste to the defect surfaces and shape in situ for dental and craniofacial reconstructions with the minimal access. Also, the use of defensive antibacterial coating (DAC) has been reported to be easily applied in on the grafts, during anterior cruciate ligament reconstruction [ 29 ]. Previous studies reported that CPC, even containing pyrogens and chopped fibers, could be rendered injectable via a 10-gauge needle [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Novel nanographene oxide-calcium phosphate cement inhibits Enterococcus faecalis biofilm and supports dental pulp stem cells

Weir

Lei

et al. 2021

J Orthop Surg Res

View full text Add to dashboard Cite

Background Enterococcus faecalis (E. faecalis) is the most recovered species from the root canals after failed root canal treatment. Calcium phosphate bone cement (CPC) scaffold is promising for applications in endodontic treatment as a kind of root canal sealer. Graphene oxide (GO) has been extensively considered as a kind of promising nano-materials for antibacterial applications. In the present study, an injectable CPC-chitosan paste containing GO was developed for promising endodontic therapy. The antibacterial properties of this paste against E. faecalis biofilms as well as the support for human dental pulp stem cells (hDPSCs) were investigated. Methods CPC-chitosan composite with or without GO injectable scaffold was fabricated. The hDPSC growth and viability on scaffolds were investigated by live/dead assay. Antibacterial effects against E. faecalis biofilms were determined in clinical detin block samples. Results The antibacterial CPC-chitosan-GO disks had excellent hDPSC support with the percentages of live cells at around 90%. CPC-chitosan-GO also had greater antibacterial activity on E. faecalis than that of CPC-chitosan control using detin block models (p < 0.05). Conclusions The injectable CPC-chitosan-GO paste had strong effects on inhibition E. faecalis and hDPSC support, which could fill the void of adjusting paste to the defect and shaping in situ for promising endodontic therapy.

show abstract

“…Covalently immobilized AG coatings have shown good antifouling properties with significant reduction in bacterial and protein adhesion as well as inhibition of biofilm formation compared to the uncoated surfaces. − Hyaluronic acid (HA) is an anionic glycosaminoglycan (GAG) polysaccharide that attracts water molecules and forms viscous hydrogels . An antifouling and fast-resorbable hydrogel coating based on graft copolymers of HA with poly- d , l -lactic acid (PLA), called Defensive Antibacterial Coating (DAC), has been recently developed for orthopedic and dental applications . Heparin (HEP) is another GAG, whose negatively charged sulfate and sulfamate groups contribute to its anticoagulant and antithrombotic properties in addition to inhibiting bacterial adhesion and biofilm formation. , However, the antibacterial activity of HEP is still debatable since free HEP has been shown to stimulate Staphylococcus aureus ( S. aureus , a major human bacterial pathogen) biofilm formation, and under some circumstances, HEP coatings may even promote S. aureus attachment. − …”

Section: General Antifouling and Bactericidal Strategiesmentioning

confidence: 99%

“…54 An antifouling and fast-resorbable hydrogel coating based on graft copolymers of HA with poly-D,L-lactic acid (PLA), called Defensive Antibacterial Coating (DAC), has been recently developed for orthopedic and dental applications. 55 Heparin (HEP) is another GAG, whose negatively charged sulfate and sulfamate groups contribute to its anticoagulant and antithrombotic properties in addition to inhibiting bacterial adhesion and biofilm formation. 56,57 However, the antibacterial activity of HEP is still debatable since free HEP has been shown to stimulate Staphylococcus aureus (S. aureus, a major human bacterial pathogen) biofilm formation, and under some circumstances, HEP coatings may even promote S. aureus attachment.…”

Section: General Antifouling and Bactericidalmentioning

confidence: 99%

Polymer-Based Coatings with Integrated Antifouling and Bactericidal Properties for Targeted Biomedical Applications

Mitra

Kang

Neoh

2021

ACS Appl. Polym. Mater.

View full text Add to dashboard Cite

One of the most detrimental consequences of surface colonization by bacteria is healthcare-associated infections (HAIs), which contribute to increased patient mortality and morbidity. Medical devices inserted into the body provide a route for bacterial migration and conducive surfaces for their attachment and proliferation. Antibacterial coatings can potentially minimize bacterial colonization and consequently reduce the occurrence of HAIs. Antibacterial coatings function by either inhibiting the attachment of bacteria (antifouling coatings) or killing bacteria attached to the surface and/or in the vicinity (bactericidal coatings). On an antifouling coating, any bacterium that manages to attach will proliferate, while on bactericidal coatings, the accumulation of dead bacteria and debris provides opportunities for other bacteria to colonize the surface. As such, the integration of antifouling and bactericidal functionalities in a single coating combines the advantages of each, increasing the probability that bacterial colonization can be successfully inhibited. This Review highlights recent developments in dual-functional polymer-based antibacterial coatings for specific biomedical applications. General strategies for endowing surfaces with either antifouling or bactericidal polymeric coatings are first discussed, followed by more detailed descriptions of coatings with integrated antifouling and bactericidal functionalities that target the important biomedical applications: blood-contacting devices, orthopedic implants, wound dressings, ocular devices, urinary catheters, endotracheal tubes, and hospital textiles. The importance of tailoring the coatings to meet the specific constraints and requirements of the intended application beyond the antibacterial functionality is emphasized, and finally, the potential challenges in translating such coatings to clinical application are highlighted.

show abstract

Defensive Antibacterial Coating (DAC®) for prevention of infection in ACL reconstruction: a feasibility study

Cited by 10 publications

References 21 publications

Comparable outcome for autografts and allografts in primary medial patellofemoral ligament reconstruction for patellofemoral instability: systematic review and meta-analysis

Comparable outcome for autografts and allografts in primary medial patellofemoral ligament reconstruction for patellofemoral instability: systematic review and meta-analysis

Novel nanographene oxide-calcium phosphate cement inhibits Enterococcus faecalis biofilm and supports dental pulp stem cells

Polymer-Based Coatings with Integrated Antifouling and Bactericidal Properties for Targeted Biomedical Applications

Contact Info

Product

Resources

About