Defensins in Ulcerative Colitis

Liu, Zhanju; Yang, Yurong

doi:10.5772/25626

Cited by 1 publication

(1 citation statement)

References 130 publications

(119 reference statements)

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“…Defensins contribute to host immunity and to maintain the balance between pathogens and normal flora [71], creating small micropores in the bacterial membranes: this causes a damage to the cell structural integrity and the consequent breakdown of the bacterial cell. Therefore, defensins, thanks to this antimicrobial quality, protect the host epithelium and stem cells from virulent pathogens and also contribute to regulate the number and composition of commensal microbiota [72]. It seems that α-defensins influence the composition of the small intestinal commensal microbiota and the presence of interleukin-17-producing T cells in the lamina propria [73].…”

Section: Beta-defensinsmentioning

confidence: 99%

Usefulness of Faecal Markers in Cow’s Milk Protein Immunomediated Reactions

Baldassarre¹,

Panza²,

Laforgia³

2016

Milk Proteins - From Structure to Biological Properties and Health Aspects

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Cow's milk protein allergy (CMPA) affects children most commonly than adults, with symptoms usually developing before 1 year of age and within 1 week after the intake of cow's milk. Food allergies can be divided into: IgE mediated and non-IgE mediated. Some reactions may include both mechanisms (mixed type). The most studied faecal Markers , so far, are calprotectin, Tumor necrosis factor-alpha (TNF-α), beta-defensin and eosinophil cationic protein (ECP). Calprotectin belongs to the S-100 family of calcium-binding proteins and seems to be involved in the regulation of inflammation. Faecal calprotectin (FC) values are significantly higher in infants suspected of having CMPA than in a comparison group of healthy infants. Moreover, there is a significant decrease in FC in infants with CMPA after a period of dietary antigen elimination, although levels use to remain higher than in age-and diet-matched comparisons. TNF-α is a cytokine involved in systemic inflammation and is one of the cytokines that make up the acute phase reaction. TNF-α expression in the epithelial cells and mononuclear cells in the lamina propria is markedly increased in FPIES patients. TNF-α is also increased in the stools of patients with gastrointestinal milk allergy after milk challenge. Defensins are small (~29 to 42 amino acid) cationic arginine and cysteine rich, amphipathic peptides with a molecular weight of 3-5 kDa. They can be classified into three groups: α-, β-and θ-defensins. Among them, only α-and β-defensins are expressed in humans. Defensins display various functions, including antimicrobial activity and also act as chemoattractant. They contribute to host immunity and to maintain the balance between pathogens and normal flora. Beta-defensins values detected in infants with a previous diagnosis of CMPA prior to the oral food challenge, and during each provocation do not seem to show significant changes. ECP is a single-chain, zinc-containing protein with a molecular weight ranging from 16 to 22 kDa and is one of the most important proteins in the granules of eosinophil granulocytes. Infants with atopic eczema exhibit a specific faecal protein pattern characterized by an increase in both ECP and TNF-α. The faecal concentration of ECP enhances particular

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Section: Beta-defensinsmentioning

confidence: 99%