“…For example, a TF gene MYB42, a target of three key regulators (MO2, ASN3, and JRG21) (Figure 4b, Table S9), which was involved in the cell wall structure by repressing genes of the lignin pathways (Sonbol et al, 2009), was also predicted to be associated with lignin synthesis through GENIE3 method (Figure 7c). Other TF target genes, belonging to WRKY, bHLH, and NAC families which were reported to be important factors in plant-pathogen interactions (Amorim et al, 2017;Campos et al, 2022), were found to associate with defence hormone signalling, ROS burst, and HR defence (Figure 7b-d,g), indicating the accuracy of our prediction tool to reveal the interplay among cell type-specific regulatory networks.…”