Defects in insulin signaling pathways in ovarian steroidogenesis and other tissues in polycystic ovary syndrome (PCOS)

Diamanti-Kandarakis, Evanthia; Argyrakopoulou, Georgia; Economou, Frangiskos; Kandaraki, Eleni; Koutsilieris, Michael

doi:10.1016/j.jsbmb.2008.03.014

Cited by 82 publications

(79 citation statements)

References 52 publications

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“…By facilitating the stimulatory role of LH, hyperinsulinaemia leads to further increase in ovarian androgen production in theca calls. 32 High insulin can also serve as a co-factor to stimulate adrenocorticotropic hormone-mediated androgen production in the adrenal glands. 33 Moreover, an insulin-induced decrease in the production of SHBG in the liver increases the amount of free bioavailable androgens.…”

Section: Insulin Resistancementioning

confidence: 99%

Polycystic ovary syndrome: a common reproductive syndrome with long-term metabolic consequences

Yau

Cheung

et al. 2017

Hong Kong Med J

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Section: Insulin Resistancementioning

confidence: 99%

Polycystic ovary syndrome: a common reproductive syndrome with long-term metabolic consequences

Yau

Cheung

et al. 2017

Hong Kong Med J

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“…19 AMH is expressed by granulosa cells of women at the reproductive age to control the formation of primary follicles and recruitment by FSH. 21 PCOS women have a high concentration of AMH in serum and follicular fluid. This results in increased number of antral follicles and failure of further growth.…”

Section: Mini Reviewmentioning

confidence: 99%

“…Inhibin-B inhibits FSH production and stimulated thecal cells to produce androgens. 21 Vascular endothelial growth factor (VEGF) is expressed in granulosa cell, theca cells and follicular fluid. 15 It plays a role in follicular maturation, oocyte quality, fertilization and embryos development.…”

Section: Mini Reviewmentioning

confidence: 99%

“…In PCOS. 15,21,23 VEGF is low in PCOS which means oocyte immaturity, low fertilization rate and bad quality of embryos, which may lead to a high incidence of miscarriages.…”

Section: Mini Reviewmentioning

confidence: 99%

“…Deficiency of IL12 and increased level of IL13 in PCOS mean immaturity and bad quality of oocytes, low rate of fertilization and pregnancy. 15,21,23 Tumours necrosis factor alpha (TNFalpha) plays a role in regulating follicular growth, steroidogenesis and apoptosis. High concentration of TNFalpha is inversely proportion to oestradiolconcentrations in follicular fluid and indicated bad quality ovum and embryo.…”

mentioning

confidence: 99%

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Polycystic Ovarian Syndrome (PCOS) this Mysterious Disease

Eissa¹

2017

MOJWH

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Interactions between metabolic and reproductive functions in the resumption of postpartum fecundity

Valeggia

Ellison

2009

American J Hum Biol

115

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Lactation has long been recognized as a major determinant of interbirth intervals. The temporal pattern of nursing has been proposed as the mechanism behind lactational amenorrhea. We present a new model of the dynamic regulation of lactational amenorrhea that identifies maternal energy availability as the main determinant of ovarian resumption. Variation in the intensity of lactation remains a component of the model as a determinant of the absolute energetic cost of milk production. But maternal energy supply determines net energy availability; a larger energy supply leaves a greater net energy surplus than a smaller energy supply (lactation costs being equal). We characterize the hormonal postpartum profile of 70 lactating Toba women of Argentina. We use C-peptide, which reflects maternal insulin production, as a measure of energy availability. Initially low, insulin production rises as the postpartum period progresses, reflecting the declining metabolic load of lactation. A short period of supernormal insulin production precedes menstrual resumption. The high levels of insulin may play a role in stimulating the resumption of ovarian activity, which in turn may help to resolve the transient period of insulin resistance. The dynamics of insulin sensitivity during lactation would aid in synchronizing the resumption of ovarian function with a reduction in the energy demands of milk production. This hypothesis is supported by the sustained weight gain experienced by lactating women during the months preceding the first postpartum menses. The link between fecundity and energy balance could serve as a mechanism for adjusting the duration of lactational amenorrhea to the relative metabolic load of lactation.

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Defects in insulin signaling pathways in ovarian steroidogenesis and other tissues in polycystic ovary syndrome (PCOS)

Cited by 82 publications

References 52 publications

Polycystic ovary syndrome: a common reproductive syndrome with long-term metabolic consequences

Polycystic ovary syndrome: a common reproductive syndrome with long-term metabolic consequences

Polycystic Ovarian Syndrome (PCOS) this Mysterious Disease

Interactions between metabolic and reproductive functions in the resumption of postpartum fecundity

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