A combination of video polarization microscopy and extensive digital line pattern analysis has been invoked to examine in quantitative detail the transformation of a lamellar into a "labyrinthine" magneticstripe domain pattern. The evolution of disorder is found to be mediated by a sequence of transverse, "smectic" instabilities culminating in the generation of disclination dipoles. Their subsequent continuous "unbinding" facilitates the formation of a globally isotropic nonequilibrium pattern adopting the topology of a binary tree and displaying a well-defined morphology with a motif in the form of oblong, polygonal clusters of linear-stripe segments. PACS numbers: 6!.70.-r, 05.70.Fh, 64.70.-p, 75.70.Kw Uniaxially modulated states abound in both two-and three-dimensional condensed-matter systems. Widely studied examples include the following: the ubiquitous lamellar or smectic phases of liquid crystals [1], surfactants [2], and block copolymers [3]; linear arrays of domain walls or discommensurations stabilized by competing periodicities such as those of rare-gas atomic and simple molecular adsorbate layers and the crystalline substrates on which they are deposited [4], as well as those of intercalates and their graphite host [5]; steps decorating reconstructed surfaces of certain semiconductors [6] and metals [7]; and stripe domain phases in ferrofluids [8], Langmuir monolayers [9], and thin magnetic garnet films [10], favored by the competition between a local attractive interaction, manifesting itself in the form of a domain-wall energy, and a repulsive electrostatic or magnetostatic interaction of long range [11]. The latter class of materials, long the subject of a substantial and ongoing effort to realize a variety of devices [12], has recently received renewed attention focusing on dynamic as well as structural aspects of their characteristic "stripe" and "bubble" phases [11]. Topological considerations play an essential role, whether they pertain to the cellular network of coarsening bubble domains [13], to the melting of bubble lattices [14], to the sequence of domain-wall bifurcations in thick garnet films [15], or to the constraints governing a complex variety of disordered, nonequilibrium stripe patterns [16].In this Letter we investigate the evolution of disorder in the two-dimensional lamellar ground state of magneticstripe domains transforming the initial ordered pattern into a globally isotropic "labyrinthine" pattern [16][17][18]. We show that this process is mediated by a sequence of transverse instabilities bearing a close resemblance to those of smectic liquid crystals subjected to compressive or dilative stress [19], and culminating in the formation and subsequent "unbinding" of disclination dipoles. The emerging nonequilibrium labyrinthine patterns exhibit a characteristic density of disclination defects, symmetrically distributed between the two components of magnetization and imparting on each the topology of a binary tree. This network of disclinations delineates a welldefined local stru...