Defects in Cellular Immunity in Chronic Upper Airway Infections Are Associated With Immunosuppressive Retroviral p15E-like Proteins

Scheeren, R. A.; Keehnen, R. M. J.; Meijer, Chris J.L.M.; Baan, S. Van Der

doi:10.1001/archotol.1993.01880160087013

Cited by 11 publications

(6 citation statements)

References 20 publications

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“…Strasnick et al 14 have identified a noncytotoxic soluble factor produced by human squamous cell cancer of head and neck that inhibits the generation of IL‐2‐activated cytotoxicity of PMNCs. Another group of investigators has suggested that during chronic infections of the upper respiratory tract, immunosuppressive retroviral P15E‐like proteins are released, which are probably responsible for the partial immune dysfunctions in patients with cancer 15 . Our studies show that a deficiency of zinc may account for decreased IL‐2 production and changes in the subpopulation of lymphocytes.…”

Section: Discussionmentioning

confidence: 49%

“…Another group of investigators has suggested that during chronic infections of the upper respiratory tract, immunosuppressive retroviral P15E-like proteins are released, which are probably responsible for the partial immune dysfunctions in patients with cancer. 15 Our studies show that a deficiency of zinc may account for decreased IL-2 production and changes in the subpopulation of lymphocytes. It is therefore important that the zinc status of cancer patients be properly defined so that these cases are managed appropriately.…”

Section: Otolaryngology-head and Neck Surgerymentioning

confidence: 58%

“…However, zinc status of their subjects was not determined. Depressed immune functions of patients with head and neck cancer have been attributed to the presence of both serum inhibitory factors and immune cell dysfunctions 14,15 . The nature of the inhibitory factors is not well understood.…”

Section: Discussionmentioning

confidence: 99%

“…Depressed immune functions of patients with head and neck cancer have been attributed to the presence of both serum inhibitory factors and immune cell dysfunctions. 14,15 The nature of the inhibitory factors is not well understood. Strasnick et al 14 have identified a noncytotoxic soluble factor produced by human squamous cell cancer of head and neck that inhibits the generation of IL-2-activated cytotoxicity of PMNCs.…”

Section: Otolaryngology-head and Neck Surgerymentioning

confidence: 99%

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Trace Elements in Head and Neck Cancer Patients: Zinc Status and Immunologic Functions

Prasad

Kaplan

Beck

et al. 1997

Otolaryngol.--head neck surg.

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In this study we have assessed zinc status and zinc-dependent cell-mediated immune functions (interleukin-2 production by mononuclear cells, natural killer cell lytic activity, and interleukin-1 beta production by mononuclear cells) in adult patients with squamous cell carcinoma of the upper aerodigestive tract at diagnosis and before any therapy was instituted. Inasmuch as significant interactions between zinc, copper, and iron exist, we also assayed the plasma copper level, serum iron level, and total iron-binding capacity in our patients. We recruited 30 cancer subjects and 21 control subjects. On the basis of cellular zinc criteria, we diagnosed a mild deficiency of zinc in 53% of cancer subjects. The plasma zinc level was not decreased in our subjects. A univariate analysis was applied by use of one-way analysis of variance comparing study variables among the three study groups (controls and zinc-deficient and zinc-sufficient cancer patients) and Tukey's multiple comparison test, and we showed that interleukin-2 production and natural killer lytic activity were decreased in zinc-deficient cancer patients. Interleukin-1 beta production (ELISA assay) was increased in both zinc-deficient and zinc-sufficient groups. Plasma copper level was not different, but the iron utilization was decreased in both groups of cancer subjects. We conclude that zinc deficiency and zinc-dependent immunologic dysfunctions are present in more than half of the patients with head and neck cancer in the Detroit area.

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Section: Discussionmentioning

confidence: 49%

Section: Otolaryngology-head and Neck Surgerymentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Otolaryngology-head and Neck Surgerymentioning

confidence: 99%

See 2 more Smart Citations

Trace Elements in Head and Neck Cancer Patients: Zinc Status and Immunologic Functions

Prasad

Kaplan

Beck

et al. 1997

Otolaryngol.--head neck surg.

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“…In these patients with hampered chemotactic responsiveness, p15E‐related inhibitory factors were found in serum as well, and it was hypothesized that these factors could interfere with the receptors for fMLP. In a subsequent study by another group in patients with chronic rhinosinusitis with or without nasal polyps, defects in cellular immunity associated with the presence of p15E‐related proteins were found in approximately 90% of patients 52 . These findings suggested that chronic inflammation of the upper airway epithelium in general was associated with defects in cellular immunity 52 …”

Section: Defects In Monocyte Polarization In Cprmentioning

confidence: 96%

Thymosin α1: a novel therapeutic option for patients with refractory chronic purulent rhinosinusitis

Dalm

Wit

Drexhage

2012

Annals of the New York Academy of Sciences

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Chronic purulent rhinosinusitis (CPR) is an inflammatory condition of unknown origin. Although various medical and surgical treatment modalities are available, 5-10% of patients remain refractory. Immune deficiency is one of the underlying risk factors for this disease. Earlier studies demonstrated disturbances in cell-mediated immunity and defects in monocyte chemotaxis in CPR. Treatment with the thymic hormone preparation thymostimulin led to significant clinical improvement in patients and in vitro restoration of monocyte chemotaxis. Unfortunately, thymostimulin became unavailable, which has led to recent interest in the immunomodulatory effects of the thymic peptide thymosin α1, which has demonstrated some benefit for CPR. Our current in vitro work focuses on the potential effects of thymosin α1 on monocyte function and gene expression profiles in order to understand its effects and mechanisms of action. Future clinical studies will evaluate the potential significance of thymosin α1 in treatment of CPR patients.

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Immunosuppressive retroviral peptides: Immunopathological implications for immunosuppressive influences of retroviral infections

Haraguchi

Good

Cianciolo

et al. 1997

Journal of Leukocyte Biology

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Defects in Cellular Immunity in Chronic Upper Airway Infections Are Associated With Immunosuppressive Retroviral p15E-like Proteins

Cited by 11 publications

References 20 publications

Trace Elements in Head and Neck Cancer Patients: Zinc Status and Immunologic Functions

Trace Elements in Head and Neck Cancer Patients: Zinc Status and Immunologic Functions

Thymosin α1: a novel therapeutic option for patients with refractory chronic purulent rhinosinusitis

Immunosuppressive retroviral peptides: Immunopathological implications for immunosuppressive influences of retroviral infections

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