Defective transition metal hydroxide-based nanoagents with hypoxia relief for photothermal-enhanced photodynamic therapy

Abstract

Defective black cobalt hydroxide-based nanoagents for efficient oxygen-evolving phototherapy.

Recent Advances in Strategies for Addressing Hypoxia in Tumor Photodynamic Therapy

“…Recently, the employment of metal-based materials to promote the decomposition of tumor endogenous H 2 O 2 to generate oxygen has attracted increasing attention. Titanium dioxide-modified palladium (Pd) nanosheets [ 123 ], Pd nanoparticles [ 124 ], defective cobalt (Co) hydroxide [ 125 ], Co 3 O 4 nanoparticles [ 126 ], iridium (Ir) oxide [ 127 , 128 ], cerium (Ce) oxide nanoparticles [ 129 , 130 ], platinum (Pt) nanozyme [ 131 , 132 ], gold (Au) nanoclusters [ 133 ], iron (Fe)-based materials [ 134 , 135 , 136 , 137 , 138 ], etc. have been used to accelerate the decomposition of H 2 O 2 to generate oxygen.…”

“…have been used to accelerate the decomposition of H 2 O 2 to generate oxygen. For instance, recently, Xu et al developed a defective cobalt hydroxide-based nanoagent for hypoxia-ameliorating photothermal-enhanced photodynamic therapy [ 125 ]. They converted cobalt hydroxide into black and defect-abundant nanosheets via oxidation, extending the absorbance range to NIR-I (750−980 nm), and achieving high photothermal conversion efficiency and enhanced H 2 O 2 decomposition activity.…”

Smart intercalation and coordination strategy to construct stable ratiometric fluorescence nanoprobes for the detection of anthrax biomarker

“…39,40 Therefore, such unique structures with an atomic level distribution of metal cations and excellent anion exchange intercalation properties allow the LDHs to have versatile applications, as catalysts, 41,42 adsorbents, 43,44 biology 39,45,46 and nanoreactors. [47][48][49] Remarkably, lanthanide-functionalized LDHs with a homogeneous distribution of lanthanide ions and synergistic effects tend to provide excellent optical materials. [50][51][52] In particular, ratiometric fluorescent DPA nanosensors were successfully constructed by intercalating organic chromophores with anionic groups into the lanthanide-based LDH interlayer.…”

Simultaneous one-step regulation of planarization and donor rotation to enhance multi-modal imaging guided therapy

“…[21][22][23] Besides, PAI and PTI can also obtain images with high resolution and contrast, originating from the thermal and acoustic wave signals during vibration relaxation. 24,25 Therefore, optimizing the structure of PSs was studied to balance radiation and non-radiation transitions for improving the performance on imaging and therapy. Recently, Tang et al proposed a strategy for improving Type I ROS and photothermal conversion efficiency by increasing the acceptor planarization and donor rotation, which has guiding significance to develop high-efficacy Type I theranostic agents.…”