Defective Rapid Eye Movements in Progressive Supranuclear Palsy

Newman, Nancy M.; Gay, Andrew J.; Stroud, Malcolm H.; Brooks, John E.

doi:10.1093/brain/93.4.775

Cited by 35 publications

(15 citation statements)

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“…Rouzaud et al [146] Ishino et al [71], one case Ishino et al [71,72] probably lijima et al [69], as a clinical case Picard and Richardson jr. [128] 1 a b c Probst and Dufresne [135] 8 a b [125] Richardson et al [142] 1964 Steele et al [168] 1965 Barbeau [16] Goldstein and Cogan [65] Jequier and De Crousaz [81] Jequier and De Crousaz [82] St~ier [169] 1966 Anastasopoulos et al [7] Messert and van Nuis [106] 1967 Anastasopoulos et al [8] Anastasopoulos et al [9] Chateau et al [33] Ismaelides et al [75] Kissel et al [87] Kissel et al [88] Szulc-Kuberska [171] 1968 Anastasopoulos et al [10] David et al [48] Ferri et al [58] Jandolo and Paolella [76] Pollingher [130] 1969 De Renzi and Vignolo [52] Gilbert and Feldman [62] Gross [68] Jenkins [80] Klawans jr [90] Mironi et al [109] Sacks [149] Wagshull and Daroff [191] Wagshull and Daroff [192] Walsh and Hoyt [193] 1970 Dehaene and Bogaerts [50] Mendell et al [105] Newman et al [122] Powell [132] Samaras [150] Sanders and Bird [151] Scot...…”

Section: Cambier Et Al [30]mentioning

confidence: 99%

Progressive supranuclear palsy 1979: an overview

1979

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Section: Cambier Et Al [30]mentioning

confidence: 99%

Progressive supranuclear palsy 1979: an overview

1979

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“…An alternative explanation for slow and long saccades is based on defective antagonist inhibition, which is suggested by ocular electromyography in PSP [25]. Simultaneous with the pulse-step excitation in agonist motorneurons is a pulse step of inhibition in the antagonists during a normal saccade [271.…”

Section: Slow Saccades Have Been Reported In a Variety Ofmentioning

confidence: 99%

The ocular motor defects in progressive supranuclear palsy

Troost

Daroff

1977

Annals of Neurology

168

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The results of quantitative infrared horizontal eye movement recordings in 8 patients with progressive supranuclear palsy are presented. Some of the patients had total paralysis of vertical movements, but none had completely lost the ability to perform horizontal eye movements. All patients had a defect in ocular fixation previously undescribed in this condition: the universal presence of square-wave jerks. Analysis of refixation saccades demonstrated hypometria, slow velocity/amplitude relationships, and profound prolongation of duration. The pursuit abnormality, characterized clinically by "cogwheel" eye movements, represented the inability to match eye velocity to target velocity. The ratio of peak eye velocity to peak target velocity (pursuit gain) was 0.2 to 0.5. Defects in the vestibuloocular reflex included inability to increase the gain of the reflex (ratio of peak eye velocity to head velocity) during viewing of a visible, stationary target and failure to suppress the reflex when viewing a target rotating with the head.

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“…In a clinical context, Yee et al (1985, p. 938) noted that due to the "maximal recruitment of motoneurons and extraocular muscle fibers […] during large saccades […] it would be expected that most disorders that impair the recruitment of motoneurons and muscle fibers or that otherwise interfere with the contraction of muscle fibers will decrease the peak velocity." Indeed, several pathologies are associated with alterations in saccadic peak velocity (Anderson & MacAskill, 2013), including progressive supranuclear palsy (Newman, Gay, Stroud, & Brooks 1970), Huntington's disease (Starr, 1967), and spinocerebellar degeneration (Zee, Optican, Cook, Robinson, & Engel, 1976). Therefore, it is crucial that amplitude and peak velocity of saccades can be accurately measured and restored from the recorded data.…”

Section: Introductionmentioning

confidence: 99%

The effect of sampling rate and lowpass filters on saccades – A modeling approach

2017

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The study of eye movements has become popular in many fields of science. However, using the preprocessed output of an eye tracker without scrutiny can lead to lowquality or even erroneous data. For example, the sampling rate of the eye tracker influences saccadic peak velocity, while inadequate filters fail to suppress noise or introduce artifacts. Despite previously published guiding values, most filter choices still seem motivated by a trial-and-error approach, and a thorough analysis of filter effects is missing. Therefore, we developed a simple and easy-to-use saccade model that incorporates measured amplitude-velocity main sequences and produces saccades with a similar frequency content to real saccades. We also derived a velocity divergence measure to rate deviations between velocity profiles. In total, we simulated 155 saccades ranging from 0.5°to 60°a nd subjected them to different sampling rates, noise compositions, and various filter settings. The final goal was to compile a list with the best filter settings for each of these conditions. Replicating previous findings, we observed reduced peak velocities at lower sampling rates. However, this effect was highly non-linear over amplitudes and increasingly stronger for smaller saccades. Interpolating the data to a higher sampling rate significantly reduced this effect. We hope that our model and the velocity divergence measure will be used to provide a quickly accessible ground truth without the need for recording and manually labeling saccades. The comprehensive list of filters allows one to choose the correct filter for analyzing saccade data without resorting to trial-and-error methods.

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Defective Rapid Eye Movements in Progressive Supranuclear Palsy

Cited by 35 publications

References 0 publications

Progressive supranuclear palsy 1979: an overview

Progressive supranuclear palsy 1979: an overview

The ocular motor defects in progressive supranuclear palsy

The effect of sampling rate and lowpass filters on saccades – A modeling approach

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