“…Interestingly, PGE 2 -mediated activation of PKA/EPAC was reported to downregulate NET release (Domingo-Gonzalez, et al, 2016; Shishikura, et al, 2016). This is of high importance in hematopoietic stem cell transplanted (HSCT) patients who have been reported to harbor high levels of PGE 2 in the serum and bronchoalveolar lavage fluid (Ballinger, et al, 2007; Cayeux, et al, 1993; Coomes, Hubbard, & Moore, 2011; Domingo-Gonzalez, et al, 2016; Domingo-Gonzalez & Moore, 2013). Neutrophils from these patients are unable to induce NET release upon phorbol myristate acetate stimulation or bacterial encounter (Domingo-Gonzalez, et al, 2016).…”