Defective production of interleukin-1 beta in patients with type 2 diabetes mellitus: Restoration by proper glycemic control

Kousathana, Foteini; Georgitsi, Marianna; Lambadiari, Vaia; Giamarellos‐Bourboulis, Evangelos J.; Dimitriadis, George; Mouktaroudi, Maria

doi:10.1016/j.cyto.2016.11.009

Cited by 24 publications

(13 citation statements)

References 20 publications

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“…They further showed that stimulation of PEMs isolated from diabetic mice with IL-4 caused an enhanced arginase activity (146). Kousathana et al have demonstrated that circulating monocytes isolated from diabetic patients produce higher levels IL-6, while having an impaired activation of the NLRP3 inflammasome and subsequently reduced IL-1β production (147). However, they showed that proper glycemic control would restore such modifications.…”

Section: Macrophagesmentioning

confidence: 99%

The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System

et al. 2020

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Metabolic abnormalities such as dyslipidemia, hyperinsulinemia, or insulin resistance and obesity play key roles in the induction and progression of type 2 diabetes mellitus (T2DM). The field of immunometabolism implies a bidirectional link between the immune system and metabolism, in which inflammation plays an essential role in the promotion of metabolic abnormalities (e.g., obesity and T2DM), and metabolic factors, in turn, regulate immune cell functions. Obesity as the main inducer of a systemic low-level inflammation is a main susceptibility factor for T2DM. Obesity-related immune cell infiltration, inflammation, and increased oxidative stress promote metabolic impairments in the insulin-sensitive tissues and finally, insulin resistance, organ failure, and premature aging occur. Hyperglycemia and the subsequent inflammation are the main causes of micro-and macroangiopathies in the circulatory system. They also promote the gut microbiota dysbiosis, increased intestinal permeability, and fatty liver disease. The impaired immune system together with metabolic imbalance also increases the susceptibility of patients to several pathogenic agents such as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Thus, the need for a proper immunization protocol among such patients is granted. The focus of the current review is to explore metabolic and immunological abnormalities affecting several organs of T2DM patients and explain the mechanisms, whereby diabetic patients become more susceptible to infectious diseases.

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Section: Macrophagesmentioning

confidence: 99%

The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System

et al. 2020

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“…IL-1R activation can drive a variety of inflammatory mediators (e.g., interleukin 6, tumor necrosis factor α) to induce host protection (Gottipati et al, 2008 ). Hyperglycemia has been suggested to cause dysregulated innate immunity (Jafar et al, 2016 ; Kousathana et al, 2017 ). In addition, innate immunity-induced inflammation is important for the pathogenesis and disease progression of both type 1 and type 2 diabetes (Prajapati et al, 2014 ; Cabrera et al, 2016 ; Wada and Makino, 2016 ; Mistry et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-146a-5p Mediates High Glucose-Induced Endothelial Inflammation via Targeting Interleukin-1 Receptor-Associated Kinase 1 Expression

Peng

Wang

2017

Front. Physiol.

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Background and Aims: Interleukin-1 receptor-associated kinase-1 (IRAK-1) is critical for mediating toll-like receptor and interleukin-1 receptor signaling. In this study, we have examined whether IRAK-1 expression is altered in high glucose (HG)-stimulated human aortic endothelial cells (HAECs), and whether microRNAs (miRs) target IRAK-1 to regulate HG-induced endothelial inflammation.Methods: HAECs were treated with HG for 24 and 48 h. Real-time PCR, Western blot, monocyte adhesion assay, bioinformatics analysis, TaqMan® arrays, microRNA mimic or inhibitor transfection, luciferase reporter assay and siRNA IRAK-1 transfection were performed. The aortic tissues from db/db type 2 diabetic mice were examined by immunohistochemistry staining.Results: HG time-dependently increased IRAK-1 mRNA and protein levels in HAECs, and was associated with increased VCAM-1/ICAM-1 gene expression and monocyte adhesion. Bioinformatic analysis, TaqMan® arrays, and real-time PCR were used to confirm that miR-146a-5p, miR-339-5p, and miR-874-3p were significantly downregulated in HG-stimulated HAECs, suggesting impaired feedback restraints on HG-induced endothelial inflammation via IRAK-1. However, only miR-146a-5p mimic transfection reduced the HG-induced upregulation of IRAK-1 expression, VCAM-1/ICAM-1 expression, and monocyte adhesion. Additionally, IRAK-1 depletion reduced HG-induced VCAM-1/ICAM-1 gene expression, and monocyte adhesion, indicating that HG-induced endothelial inflammation was mediated partially through IRAK-1. In vivo, intravenous injections of miR-146a-5p mimic prevented endothelial IRAK-1 and ICAM-1 expression in db/db mice.Conclusion: These results suggest that miR-146a-5p is involved in the regulation of HG-induced endothelial inflammation via modulation of IRAK-1; indicating that miR-146a-5p may be a novel target for the treatment of diabetic vascular complications.

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“…Studies in poorly controlled subjects with T2DM have shown attenuated increases in plasma levels of cytokines and adhesion molecules after the administration of endotoxin in vivo [ 79 ]. These defects can be partly restored after adequate glycemic control, highlighting the importance of optimal glucose management for the maintenance of appropriate immune function in DM during infections [ 80 ]. T2DM is an inflammatory disease characterized by the increased production of proinflammatory cytokines from adipose tissue/endothelial cells and insulin resistance in the liver/muscle/adipose tissue, along with inadequate β-cell function; by the time of clinical diagnosis, at least 50% of β-cell mass has been lost due to progressive destruction by oxidative stress, generated from the elevated levels of glucose and NEFAs in the circulation (glucotoxicity and lipotoxicity) [ 81 ].…”

Section: The Association Between Dm and Covid-19mentioning

confidence: 99%

Clinical Management of Diabetes Mellitus in the Era of COVID-19: Practical Issues, Peculiarities and Concerns

Koliaki

Tentolouris

Eleftheriadou

et al. 2020

JCM

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The management of patients with diabetes mellitus (DM) in the era of the COVID-19 pandemic can be challenging. Even if they are not infected, they are at risk of dysregulated glycemic control due to the restrictive measures which compromise and disrupt healthcare delivery. In the case of infection, people with DM have an increased risk of developing severe complications. The major principles of optimal care for mild outpatient cases include a patient-tailored therapeutic approach, regular glucose monitoring and adherence to medical recommendations regarding lifestyle measures and drug treatment. For critically ill hospitalized patients, tight monitoring of glucose, fluids, electrolytes, pH and blood ketones is of paramount importance to optimize outcomes. All patients with DM do not have an equally increased risk for severity and mortality due to COVID-19. Certain clinical and biological characteristics determine high-risk phenotypes within the DM population and such prognostic markers need to be characterized in future studies. Further research is needed to examine which subgroups of DM patients are expected to benefit the most from specific antiviral, immunomodulatory and other treatment strategies in the context of patient-tailored precision medicine, which emerges as an urgent priority in the era of COVID-19.

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Defective production of interleukin-1 beta in patients with type 2 diabetes mellitus: Restoration by proper glycemic control

Cited by 24 publications

References 20 publications

The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System

The Effects of Type 2 Diabetes Mellitus on Organ Metabolism and the Immune System

MicroRNA-146a-5p Mediates High Glucose-Induced Endothelial Inflammation via Targeting Interleukin-1 Receptor-Associated Kinase 1 Expression

Clinical Management of Diabetes Mellitus in the Era of COVID-19: Practical Issues, Peculiarities and Concerns

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