Defective lysosomal acidification contributes to TNFR1 mediated neuronal necroptosis in Alzheimer’s disease
Chih Hung Lo,
Jialiu Zeng,
Gavin Wen Zhao Loi
et al.
Abstract:Background: Tumor necrosis factor (TNF) receptor 1 (TNFR1) signaling mediates neuronal necroptosis in Alzheimer's disease (AD). Interaction of TNFR1 signaling axis with autolysosomal pathway and the accumulation of necrosome molecules in impaired lysosomes have been shown to lead to necroptotic neuronal death. This has been attributed to the terminal failure of the autophagic process, primarily due to lysosomal degradation dysfunction. Being the final and determining step of the autolysosomal pathway, lysosome… Show more
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