“…Goodfriend, Shey and Siegelbaum (1953) explain this on the grounds that it is impossible to administer the whole blood at a sufficient rate to raise the patient's blood fibrinogen to effective coagulant levels. Goodfriend, Shey and Siegelbaum (1953) explain this on the grounds that it is impossible to administer the whole blood at a sufficient rate to raise the patient's blood fibrinogen to effective coagulant levels.…”