Defected expression of E-cadherin in non-small cell lung cancer

Expression of E-cadherin and nm23 is associated with the clinicopathological factors of human non-small cell lung cancer in China

“…For the E-cadherin gene, only a polymorphism other than a somatic mutation was found in the Chinese patients of NSCLC under study. This is in agreement with our previous report [7]. In addition, any mutation was not identified in the nm23 gene.…”

“…Evidence for Ecadherin mRNA expression reported in this study is consistent with those of Kase's research group [4] and others [19,20]. The results obtained in the present study supported the idea that E-cadherin plays an important role in the development of malignant phenotype in NSCLC [7]. The association between decreased expression of nm23 and metasta- sis was identified in many, but not in all cancers [13][14][15][16]21,22].…”

“…Accumulating experimental evidence showed that E-cadherin functions as a potent invasion suppressor gene. Our studies, as well as others suggested that reduction and/or loss of E-cadherin is found to correlate with increased lymph node metastasis [4,7]. However, despite there is a consensus on reduced expression of E-cadherin protein in NSCLC, the aberrant expression of mRNA level remains unclear.…”

“…Subsequent sequence analysis revealed a single polymorphism in exon 13 at codon 692 (GCC-GCT, Fig. 2B) that was previously published [7]. Any aberrant SSCP pattern of the nm23 gene was not identified in NSCLC under investigation (data not shown, the results are available from the corresponding author on request).…”

“…We previously examined 40 pairs of cases of NSCLC and controls, evaluated molecular structure and protein expression profiles of the E-cadherin gene [7]. We also examined protein expression patterns of nm23 in NSCLC (data not shown, the results are available from the corresponding author on request).…”