Defect of memorizing of hippocampal-mammillary origin: a review

Barbizet, J

doi:10.1136/jnnp.26.2.127

Cited by 153 publications

(57 citation statements)

References 16 publications

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“…Particularly striking is the recent discovery that in patients who have suffered from colloid cysts the volume of the mammillary bodies is consistently correlated with scores on various tests of recall (Tsivilis et al, 2008). Not surprisingly, the mammillary bodies have typically been seen as a hippocampal relay to the anterior thalamus via the mammillothalamic tract (Papez, 1937;Barbizet, 1963;Aggleton and Brown, 1999). This overview of mammillary body function accords with evidence that damage to the mammillothalamic tract, following strokes in humans ( Van der Werf et al, 2000;Van der Werf et al, 2003) or following lesions in rats (Vann and Aggleton, 2003), disrupts memory.…”

Section: Introductionmentioning

confidence: 49%

Selective disconnection of the hippocampal formation projections to the mammillary bodies produces only mild deficits on spatial memory tasks: Implications for fornix function

et al. 2011

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ABSTRACT:It is now clear that the integrity of the fornix is important for normal mnemonic function. The fornix, however, is a major white matter tract, carrying numerous hippocampal formation afferents and efferents, and it is not known which specific components support memory processes. Established theories of extended hippocampal function emphasize the sequential pathway from the hippocampal formation (i.e., subicular complex) to the mammillary bodies and, thence, to the anterior thalamus, as pathology in each of these structures is implicated in anterograde amnesia in humans and spatial memory deficits in rats. The specific importance of the hippocampal formation projections that just innervate the mammillary bodies has, however, never been tested. This study isolated these specific projections in the rat by selectively cutting the descending component of the postcommissural fornix. Two successive, cohorts of rats with these tract lesions were tested on working memory tasks in the water-maze, T-maze, and radial-arm maze. Disconnecting the descending postcommissural fornix had only a mild effect or sometimes no apparent effect on the performance of these spatial memory tasks, even though tracing experiments confirmed the loss of hippocampal formation-mammillary projections. One implication is that the spatial deficits found in rats following standard fornix lesions are only partly attributable to the loss of projections from the hippocampal formation to the mammillary bodies. Perhaps more surprising, the behavioral impact of cutting the descending postcommissural fornix in rats appeared appreciably less than the effect of either mammillary body or mammillothalamic tract lesions. The present experiments show that the mammillary bodies can still effectively support spatial memory in the absence of their dense subicular complex inputs, so revealing the importance of the other afferents for sustaining mammillary body function. This new evidence for independent functions shows that the mammillary bodies are more than just a hippocampal relay. V V C 2010 Wiley-Liss, Inc.

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Section: Introductionmentioning

confidence: 49%

Selective disconnection of the hippocampal formation projections to the mammillary bodies produces only mild deficits on spatial memory tasks: Implications for fornix function

et al. 2011

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“…1 4-6 These structures are part of the well known memory circuit of the hippocampo-fornico-mammillo-thalamo-cingulate system, which is known as the Papez circuit. 7 In other cases, damage to the dorsomedial nucleus has been considered critical for amnesia. This nucleus has massive reciprocal connections with the orbitofrontal cortex as well as with the dorsolateral prefrontal cortex.…”

mentioning

confidence: 99%

A case of frontal network amnesia

Tanji

Suzuki²,

Fujii³

et al. 2003

Journal of Neurology, Neurosurgery &Amp; Psychiatry

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“…The lesions in the experimental group included both pyriform cortex and ventral hippocampus. Tbey are similar to the ablations which are reported to reduce the ability of neurosurgical patients to learn new information (Barbizet, 1963). I t may be that production of a deficit in acquisition of discriminations by cats requires lesions of both pyriform cortex and hippocampus.…”

Section: Dlscussionmentioning

confidence: 64%

Impaired acquisition of a successive visual pattern discrimination following hippocampal ablations in cats

Buerger

1969

Psychon Sci

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Defect of memorizing of hippocampal-mammillary origin: a review

Cited by 153 publications

References 16 publications

Selective disconnection of the hippocampal formation projections to the mammillary bodies produces only mild deficits on spatial memory tasks: Implications for fornix function

Selective disconnection of the hippocampal formation projections to the mammillary bodies produces only mild deficits on spatial memory tasks: Implications for fornix function

A case of frontal network amnesia

Impaired acquisition of a successive visual pattern discrimination following hippocampal ablations in cats

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