Defect of glucosyltransferases reduces platelet aggregation activity of Streptococcus mutans: Analysis of clinical strains isolated from oral cavities

Taniguchi, Nobuaki; Nakano, Kazuhiko; Nomura, Ryota; Naka, Shuhei; Kojima, Ayuchi; Matsumoto, Michi; Ooshima, Takashi

doi:10.1016/j.archoralbio.2010.03.017

Cited by 14 publications

(5 citation statements)

References 29 publications

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“…Over recent decades, accumulating epidemiologic data indicate that common oral diseases, such as caries, periodontal diseases, and the loss of teeth, are associated with MetS, cardiovascular diseases, and diabetes. 31,32 Although not well understood, several underlying mechanisms have been proposed: the release of inflammatory mediators (interleukin-1α and -1β and tumor necrosis factor-α) into the circulation that play key role in atherogenesis 33 results in macrophage stimulation by the lipopolysaccharides of these microorganisms, 34 enhancing platelet aggregation and thereby increasing the risk of thrombosis, 35 triggering host stress responses in endothelial cells. 36 The number of teeth with caries was associated with increased MetS risk in univariate analysis, and remained statistically significant despite the fact that the effect size was attenuated after adjustment for explanatory variables.…”

Section: Discussionmentioning

confidence: 99%

Relationship between dental caries and metabolic syndrome among 13 998 middle‐aged urban Chinese

Cao

Wang

Zhou

et al. 2016

Journal of Diabetes

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Section: Discussionmentioning

confidence: 99%

Relationship between dental caries and metabolic syndrome among 13 998 middle‐aged urban Chinese

Cao

Wang

Zhou

et al. 2016

Journal of Diabetes

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“…Likewise, none of the isolates harbored the gtfBC gene fusion (Table 1; see also Fig. S1 in the supplemental material), so differences in adhesion that may result from carrying either the two tandemly arranged genes or the gene fusion (76) are not fundamental to the development of caries. Finally, S. mutans is a member of the oral biota, and as such it is in constant interaction with many other microorganisms, as well as with host factors, all likely to play a role in caries pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

Distribution of Putative Virulence Genes in Streptococcus mutans Strains Does Not Correlate with Caries Experience

Argimón

Caufield

2011

J Clin Microbiol

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Streptococcus mutans, a member of the human oral flora, is a widely recognized etiological agent of dental caries. The cariogenic potential of S. mutans is related to its ability to metabolize a wide variety of sugars, form a robust biofilm, produce copious amounts of lactic acid, and thrive in the acid environment that it generates. The remarkable genetic variability present within the species is reflected at the phenotypic level, notably in the differences in the cariogenic potential between strains. However, the genetic basis of these differences is yet to be elucidated. In this study, we surveyed by PCR and DNA hybridization the distribution of putative virulence genes, genomic islands, and insertion sequences across a collection of 33 strains isolated from either children with severe early childhood caries (S-ECC) or those who were caries free (CF). We found this genetically diverse group of isolates to be remarkably homogeneous with regard to the distribution of the putative virulence genes and genetic elements analyzed. Our findings point to the role of other factors in the pathogenesis of S-ECC, such as uncharacterized virulence genes, differences in gene expression and/or enzymatic activity, cooperation between S. mutans strains or with other members of the oral biota, and host factors.

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“…The process is multifactorial and involves many cell surface proteins including: the platelet aggregation associated protein (PAAP) of S. sanguinis (125), serine rich glycoproteins designated SrpA and GspB/Hsa in S. sanguinis (126) and S. gordonii (127), respectively, adhesions such as SspA and SspB in S. gordonii (122), as well as glucosyltansferases (128). …”

Section: Direct Arterial Infectionmentioning

confidence: 99%

Cardiovascular disease and the role of oral bacteria

Leishman

Lien

Ford

2010

Journal of Oral Microbiology

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In terms of the pathogenesis of cardiovascular disease (CVD) the focus has traditionally been on dyslipidemia. Over the decades our understanding of the pathogenesis of CVD has increased, and infections, including those caused by oral bacteria, are more likely involved in CVD progression than previously thought. While many studies have now shown an association between periodontal disease and CVD, the mechanisms underpinning this relationship remain unclear. This review gives a brief overview of the host-bacterial interactions in periodontal disease and virulence factors of oral bacteria before discussing the proposed mechanisms by which oral bacterial may facilitate the progression of CVD.

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Defect of glucosyltransferases reduces platelet aggregation activity of Streptococcus mutans: Analysis of clinical strains isolated from oral cavities

Cited by 14 publications

References 29 publications

Relationship between dental caries and metabolic syndrome among 13 998 middle‐aged urban Chinese

Relationship between dental caries and metabolic syndrome among 13 998 middle‐aged urban Chinese

Distribution of Putative Virulence Genes in Streptococcus mutans Strains Does Not Correlate with Caries Experience

Cardiovascular disease and the role of oral bacteria

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