Defeat followed by individual housing results in long-term impaired reward- and cognition-related behaviours in rats

Frijtag, Josefien C. von; Reijmers, Leon G.; Harst, Johanneke E. van der; Leus, I.E.; Bos, Ruud van den; Spruijt, Berry M.

doi:10.1016/s0166-4328(00)00300-4

Cited by 177 publications

(128 citation statements)

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“…This paradigm induces symptoms resembling anhedonia in depressed patients (Auriacombe et al 1997), measured as the absence of anticipatory behavior in response to sucrose rewards in these animals (Von Frijtag et al 2000. The anhedonia in rodents is a long-term effect that correlates with impaired social memory and interactions (Rygula et al 2005;Von Frijtag et al 2000) and is counteracted by imipramine (Von Frijtag et al 2002) or fluoxetine (Rygula et al 2006) as also shown in this study. Using this animal model for depression, we investigated the putative relationship among social stress, the effects of chronic fluoxetine, and 5-HT 1A and GABA B receptor function in the DRN.…”

Section: Introductionsupporting

confidence: 75%

“…The social stress procedure has been described previously ( Von Frijtag et al 2000. In short, the social defeat procedure consisted of daily resident-intruder sessions on five consecutive days.…”

Section: Animals Housing and Conditioningmentioning

confidence: 99%

“…Different animals were used for the behavioral assay and slice recordings to avoid interference of experimental procedures. The behavioral assay consisted of classical Pavlovian conditioning as previously described (Von Frijtag et al 2000;Van der Harst 2005 ). A brief conditioning stimulus (CS, 2 ϫ 60 W light-input with 1-s interval followed by an auditory signal) was repeatedly paired with an unconditioned stimulus (US, free access to 5% sucrose solution for 5 min and of which the consumption was measured).…”

Section: Animals Housing and Conditioningmentioning

confidence: 99%

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Reduced 5-HT_1A- and GABA_BReceptor Function in Dorsal Raphé Neurons Upon Chronic Fluoxetine Treatment of Socially Stressed Rats

Cornelisse¹,

Harst²,

Lodder

et al. 2007

Journal of Neurophysiology

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Cornelisse LN, Van der Harst JE, Lodder JC, Baarendse PJ, Timmerman AJ, Mansvelder HD, Spruijt BM, Brussaard AB. Reduced 5-HT 1A -and GABA B receptor function in dorsal raphé neurons upon chronic fluoxetine treatment of socially stressed rats. J Neurophysiol 98: 196 -204, 2007. First published April 25, 2007; doi:10.1152/jn.00109.2007. Autoinhibitory serotonin 1A receptors (5-HT 1A ) in dorsal raphé nucleus (DRN) have been implicated in chronic depression and in actions of selective serotonin reuptake inhibitors (SSRI). Due to experimental limitations, it was never studied at single-cell level whether changes in 5-HT 1A receptor functionality occur in depression and during SSRI treatment. Here we address this question in a social stress paradigm in rats that mimics anhedonia, a core symptom of depression. We used whole cell patch-clamp recordings of 5-HT-and baclophen-induced G-proteincoupled inwardly rectifying potassium (GIRK) currents as a measure of 5-HT 1A -and GABA B receptor functionality. 5-HT 1A -and GABA B receptor-mediated GIRK-currents were not affected in socially stressed rats, suggesting that there was no abnormal (auto)inhibition in the DRN on social stress. However, chronic fluoxetine treatment of socially stressed rats restored anticipatory behavior and reduced the responsiveness of 5-HT 1A receptor-mediated GIRK currents. Because GABA B receptor-induced GIRK responses were also suppressed, fluoxetine does not appear to desensitize 5-HT 1A receptors but rather one of the downstream components shared with GABA B receptors. This fluoxetine effect on GIRK currents was also present in healthy animals and was independent of the animal's "depressed" state. Thus our data show that symptoms of depression after social stress are not paralleled by changes in 5-HT 1A receptor signaling in DRN neurons, but SSRI treatment can alleviate these behavioral symptoms while acting strongly on the 5-HT 1A receptor signaling pathway. 1995;Pejchal et al. 2002;Shen et al. 2002;Subhash et al. 2000). Although it remains unclear by which mechanism SSRIs exert their antidepressant action, there is a clear relation between reduced 5-HT1 A receptor function and increased 5-HT levels in DRN innervated forebrain areas after SSRI treatment in rodents. If SSRIs are acutely applied, locally enhanced 5-HT levels in the DRN inhibit serotonernergic neurons through activation of the 5-HT1 A autoreceptor. This results in decreased 5-HT release in the projection areas (Artigas et al. 1996b). However, after chronic SSRI treatment, 5-HT1 A receptors are desensitized, and firing of DRN cells is restored resulting in increased 5-HT levels in the frontal cortex (Artigas et al. 1996b;Bel and Artigas 1993). Co-application of 5-HT1 A receptor antagonists appears to prevent the initial decrease of 5-HT release in the forebrain during SSRI treatment and may accelerate antidepressant responses in patients (Artigas et al. 1996b;Blier et al. 1998).These studies suggest a role for DRN 5-HT1 A autoreceptors in etiology of depression as well as in ...

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Section: Introductionsupporting

confidence: 75%

Section: Animals Housing and Conditioningmentioning

confidence: 99%

Section: Animals Housing and Conditioningmentioning

confidence: 99%

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Reduced 5-HT_1A- and GABA_BReceptor Function in Dorsal Raphé Neurons Upon Chronic Fluoxetine Treatment of Socially Stressed Rats

Cornelisse¹,

Harst²,

Lodder

et al. 2007

Journal of Neurophysiology

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“…Behaviour was scored with the help of software package The Observer Netherlands. Anticipatory behaviour was expressed in the number of behavioural transitions per minute (BT/min: see von Frijtag et al, 2000;; frequencies of ''nose pokes around the feeding area'' were counted in addition.…”

Section: Data Analysis and Statisticsmentioning

confidence: 99%

“…Subsequently, found increased levels of anticipatory behaviour on sucrose in not enriched stimulus-poor housing systems. Interestingly, decreased levels of anticipatory behaviour were found in individuals that were exposed to social defeat and solitary housing (''depressive state' ': von Frijtag et al, 2000': von Frijtag et al, , 2002. In the study of , where enriched housed rats showed less anticipatory behaviour to sucrose-rewards than standard housed rats, the presence of enrichments in a stimulus-poor cage environment may have compensated for the absence of other behavioural needs.…”

Section: Introductionmentioning

confidence: 98%

Anticipatory behaviour and stereotypical behaviour in farmed mink (Mustela vison) in the presence, absence and after the removal of swimming water

Vinke

Houx

Bos

et al. 2006

Applied Animal Behaviour Science

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Captive animals are often provided with cage enrichments in order to improve their welfare. Swimming water is an often-discussed requirement for farmed mink. The present study aimed to give insight into the value of swimming water for farmed mink by measuring anticipatory and stereotypical behaviour in subjects raised and housed in the presence and absence of swimming water and in subjects that were deprived of swimming water.The major findings of the present experiments are that: (1) there was no significant difference in anticipatory behaviour between subjects reared and housed in the presence or absence of swimming water; nor was there a significant difference in anticipatory behaviour after removing the water for 2.5 weeks, (2) there was no significant difference in stereotypical behaviour in winter in the presence, absence and after 2.5 months deprivation of swimming water, and finally, (3) there was no significant correlation between anticipatory activity and stereotypical behaviour.The results suggest that mink might not experience consequences, in the sense of increased reward-sensitivity or stereotypy levels, due to the absence of swimming water if they never experienced this incentive before, and that swimming water and an empty bath, such as used in this experiment, might be equally valued incentives for mink. #

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Brief introduction to welfare assessment: a ‘toolbox’ of techniques

Lofgren

2024

The UFAW Handbook on the Care and Management of Laboratory and Other Research Animals

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Defeat followed by individual housing results in long-term impaired reward- and cognition-related behaviours in rats

Cited by 177 publications

References 50 publications

Reduced 5-HT_1A- and GABA_BReceptor Function in Dorsal Raphé Neurons Upon Chronic Fluoxetine Treatment of Socially Stressed Rats

Reduced 5-HT_1A- and GABA_BReceptor Function in Dorsal Raphé Neurons Upon Chronic Fluoxetine Treatment of Socially Stressed Rats

Anticipatory behaviour and stereotypical behaviour in farmed mink (Mustela vison) in the presence, absence and after the removal of swimming water

Brief introduction to welfare assessment: a ‘toolbox’ of techniques

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Defeat followed by individual housing results in long-term impaired reward- and cognition-related behaviours in rats

Cited by 177 publications

References 50 publications

Reduced 5-HT1A- and GABABReceptor Function in Dorsal Raphé Neurons Upon Chronic Fluoxetine Treatment of Socially Stressed Rats

Reduced 5-HT1A- and GABABReceptor Function in Dorsal Raphé Neurons Upon Chronic Fluoxetine Treatment of Socially Stressed Rats

Anticipatory behaviour and stereotypical behaviour in farmed mink (Mustela vison) in the presence, absence and after the removal of swimming water

Brief introduction to welfare assessment: a ‘toolbox’ of techniques

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Product

Resources

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Reduced 5-HT_1A- and GABA_BReceptor Function in Dorsal Raphé Neurons Upon Chronic Fluoxetine Treatment of Socially Stressed Rats

Reduced 5-HT_1A- and GABA_BReceptor Function in Dorsal Raphé Neurons Upon Chronic Fluoxetine Treatment of Socially Stressed Rats