DEFB1 polymorphisms and salivary hBD-1 concentration in Oral Lichen Planus patients and healthy subjects

Polesello, Vania; Zupin, Luisa; Lenarda, Roberto Di; Biasotto, Matteo; Pozzato, Gabriele; Ottaviani, Giulia; Gobbo, Margherita; Crovella, Sérgio; Segat, Ludovica

doi:10.1016/j.archoralbio.2016.10.008

Cited by 17 publications

(30 citation statements)

References 20 publications

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“…These findings are similar to previous reports in SLE, but different from reports on T1D, in which the allele and genotype appeared to have a protective effect . These results could be attributable to an increase in the transcription rate of DEFB1 mRNA due to the presence of the ‐44 G allele, increasing constitutive HBD‐1 production . This could also be relevant for SLE and T1D, as observed previously .…”

Section: Discussionsupporting

confidence: 82%

“…There is currently little information regarding the role of HBD‐1/ DEFB1 in vitiligo. In the present study, we evaluated the role of serum HBD‐1 levels and three DEFB1 5′UTR polymorphisms in vitiligo, based on their previously reported association with other autoimmune diseases …”

Section: Discussionmentioning

confidence: 99%

“…mentioned that the ‐20 A allele appears to be related to lower both HBD‐1 and gene expression at the tissue level, which might also explain its role as a risk factor for human immunodeficiency virus infection . Nevertheless, recent research has failed to prove such an effect on HBD‐1 levels, meaning that the DEFB1 ‐20G/A polymorphism needs to be investigated further regarding its functional role …”

Section: Discussionmentioning

confidence: 99%

“…Certain polymorphisms in DEFB1 , the gene encoding for HBD‐1, may affect its transcription rate and the expression of HBD‐1 protein . In particular, polymorphisms in the 5′ untranslated region (UTR) of DEFB1 exert this effect by altering a putative transcription factor binding site for the nuclear factor‐κB p105 subunit …”

Section: Introductionmentioning

confidence: 99%

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Association of human beta-defensin 1 gene polymorphisms with nonsegmental vitiligo

et al. 2018

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The -44 G allele, CG genotype and GGG haplotype increased the risk for vitiligo (P < 0.02 in all cases), whereas the -20 AA genotype seems to be protective (P = 0.04). Serum HBD-1 levels were lower in patients with vitiligo than in HCs (P < 0.01), as well as in patients with active vitiligo compared with those with stable vitiligo and with HCs (P < 0.05 in both cases), CONCLUSION: Our results suggest that HBD-1 and its gene polymorphisms may modulate vitiligo susceptibility and/or disease activity. This is the first report, to our knowledge, of the association of serum HBD-1 levels and DEFB1 gene polymorphisms with vitiligo.

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Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association of human beta-defensin 1 gene polymorphisms with nonsegmental vitiligo

et al. 2018

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“…hBDs act on the innate immune response and also on signaling for the adaptive response . At present 28 hBDs are known, however the expression have been demonstrated in only four of them, of which, β‐defensin‐1 (hBD‐1) has been reported as constitutively expressed in the oral mucosa …”

Section: Introductionmentioning

confidence: 99%