Default mode network connectivity as a predictor of post‐traumatic stress disorder symptom severity in acutely traumatized subjects

Lanius, Ruth A.; Bluhm, Robyn; Coupland, Nicholas J.; Hegadoren, Kathy; Rowe, Brian H.; Théberge, Jean; Neufeld, R. W. J.; Williamson, Peter C.; Brimson, M.

doi:10.1111/j.1600-0447.2009.01391.x

Cited by 247 publications

(247 citation statements)

References 42 publications

(65 reference statements)

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“…Consistent with this, a study of resting-state functional connectivity between the posterior cingulate and other brain regions in a group of acutely traumatized adults found that the degree of connectivity with bilateral anterior cingulate region is positively associated with the severity of PTSD symptoms (i.e., the most severe cases had the greatest coordinated activity between posterior and anterior cingulate) [7] .…”

Section: Discussionmentioning

confidence: 63%

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Altered regional homogeneity in post-traumatic stress disorder: a restingstate functional magnetic resonance imaging study

et al. 2012

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Objective Little is known about the brain systems that contribute to vulnerability to post-traumatic stress disorder (PTSD). Comparison of the resting-state patterns of intrinsic functional synchronization, as measured by functional magnetic resonance imaging (fMRI), between groups with and without PTSD following a traumatic event can help identify the neural mechanisms of the disorder and targets for intervention. Methods Fifty-four PTSD patients and 72 matched traumatized subjects who experienced the 2008 Sichuan earthquake were imaged with blood oxygen level-dependent (BOLD) fMRI and analyzed using the measure of regional homogeneity (ReHo) during the resting state. Results PTSD patients presented enhanced ReHo in the left inferior parietal lobule and right superior frontal gyrus, and reduced ReHo in the right middle temporal gyrus and lingual gyrus, relative to traumatized individuals without PTSD. Conclusion Our findings showed that abnormal brain activity exists under resting conditions in PTSD patients who had been exposed to a major earthquake. Alterations in the local functional connectivity of cortical regions are likely to contribute to the neural mechanisms underlying PTSD.

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Section: Discussionmentioning

confidence: 63%

“…For example, two studies compared women with early-life trauma to healthy women [6] and examined the relationship between coordinated activity in the resting state and PTSD symptoms in an acutely traumatized sample [7] .…”

Section: Introductionmentioning

confidence: 99%

Altered regional homogeneity in post-traumatic stress disorder: a restingstate functional magnetic resonance imaging study

et al. 2012

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“…It has been suggested that DMN connectivity may have potential as a predictor of PTSD symptom severity in acutely traumatised subjects (Lanius et al, 2010). In an attempt to explore the potential of the abovementioned dysconnectivity as a biological marker for BPD, it is recommended that future studies should also carry out functional connectivity analyses in the most commonly documented comorbidities of BPD, which are MDD, attention deficit hyperactivity disorder (ADHD), and PTSD.…”

Section: Discussionmentioning

confidence: 99%

Dysregulation between emotion and theory of mind networks in borderline personality disorder

O’Neill

D'Souza

Samson

et al. 2015

Psychiatry Research: Neuroimaging

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a b s t r a c tIndividuals with borderline personality disorder (BPD) commonly display deficits in emotion regulation, but findings in the area of social cognitive (e.g., theory of mind, ToM) capacities have been heterogeneous. The aims of the current study were to investigate differences between patients with BPD and controls in functional connectivity (1) between the emotion and ToM network and (2) in the default mode network (DMN). Functional magnetic resonance imaging was used to investigate 19 healthy controls and 17 patients with BPD at rest and during ToM processing. Functional coupling was analysed. Significantly decreased functional connectivity was found for patients compared with controls between anterior cingulate cortex and three brain areas involved in ToM processes: the left superior temporal lobe, right supramarginal/inferior parietal lobes, and right middle cingulate cortex. Increased functional connectivity was found in patients compared with controls between the precuneus as the DMN seed and the left inferior frontal lobe, left precentral/middle frontal, and left middle occipital/ superior parietal lobes during rest. Reduced functional coupling between the emotional and the ToM network during ToM processing is in line with emotion-regulation dysfunctions in BPD. The increased connectivity between precuneus and frontal regions during rest might be related to extensive processing of internal thoughts and self-referential information in BPD.

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“…Moreover, a recent study investigated the relationship between default mode network connectivity and the severity of PTSD symptoms in subjects who had experienced an acute traumatic event 6-12 weeks before. The results of this study suggest that the resting-state connectivity of the posterior cingulate cortex/precuneus with the perigenual ACC and right amygdala is associated with current PTSD symptoms and that the correlation with the right amygdala predicts future PTSD symptoms (Lanius et al, 2010). Another study measuring resting-state amygdala connectivity in male veterans with PTSD (n=15) and in combat controls (n=14) showed greater positive connectivity between the amygdala and the insula in patients with PTSD than in controls, reduced positive connectivity between the amygdala and the hippocampus, and a reduced anticorrelation between the amygdala and the dorsal and rostral ACC (Sripada et al, 2012).…”

Section: Traumatic Experiences Disrupt Amygdala-prefrontal Connectivitymentioning

confidence: 71%

Traumatic Experiences Disrupt Amygdala – Prefrontal Connectivity

Oh¹

2012

The Amygdala - A Discrete Multitasking Manager

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Default mode network connectivity as a predictor of post‐traumatic stress disorder symptom severity in acutely traumatized subjects

Abstract: These results may contribute to the development of prognostic tools to distinguish between those who will and those who will not develop PTSD.

Cited by 247 publications

References 42 publications

Altered regional homogeneity in post-traumatic stress disorder: a restingstate functional magnetic resonance imaging study

Altered regional homogeneity in post-traumatic stress disorder: a restingstate functional magnetic resonance imaging study

Dysregulation between emotion and theory of mind networks in borderline personality disorder

Traumatic Experiences Disrupt Amygdala – Prefrontal Connectivity

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