Deer antler extract: Pharmacology, rehabilitation and sports medicine applications

Orassay, Aliya; Sadvokassova, Darya; Berdigaliyev, Alan; Sagintayev, Adlet; Myrzagali, Sandugash; Omarova, Zhuldyz; Toktarov, Nurlan; Liu, Dongsheng; Xie, Yingqiu

doi:10.1016/j.prmcm.2023.100316

Cited by 4 publications

(1 citation statement)

References 106 publications

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“…Recent studies have found that stimulation of the PI3K-AKT/Wnt-β-Catenin Pathways is strongly associated with HFSC activation and HF formation ( Qiu et al, 2017 ; Wang et al, 2017 ; Jin et al, 2021 ). In addition, the pilose antler has a regulatory effect on the activation of the PI3K-AKT/Wnt-β-Catenin Pathways ( Mount et al, 2006 ; Lee and Choi, 2024 ; Orassay et al, 2024 ), however, whether it regulates HFSC activation through this pathway has not been reported. Besides, in our previous study, active components extracted from pilose antler were known as PAEs.…”

Section: Introductionmentioning

confidence: 99%

Pilose antler extracts promotes hair growth in androgenetic alopecia mice by activating hair follicle stem cells via the AKT and Wnt pathways

Wang,

He,

Liu

et al. 2024

Front. Pharmacol.

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Background: Angrogenetic alopecia (AGA) is one of the most prevalent hair loss disorders worldwide. The hair follicle stem cell (HFSC) is closely related to the formation of hair follicle (HF) structure and HF self-renewal. The activation of HFSC in AGA is critical for hair growth. Pilose antler has been reported to have hair growth-promoting activity, but the mechanism of action on AGA and HFSC has not been reported.Methods: We previously extracted an active component from the pilose antler known as PAEs. In this study, we conducted experiments using AGA mice and HFSC. The effects of PAEs on hair growth in AGA mice were firstly detected, and then the mechanisms of PAEs for AGA were predicted by integrating network pharmacology and de novo transcriptomics data of pilose antler. Finally, biological experiments were used to validate the molecular mechanism of PAEs in treating AGA both in vivo and in vitro.Results: It was found that PAEs promoted hair regrowth by accelerating the activation of anagen, delaying the anagen-catagen transition. It also alleviated the morphological changes, such as hair shortening, thinning, miniaturization, and HF number reduction, and regulated the hair regeneration process of four subtypes of hair. We further found that PAEs could promote the proliferation of HFSC, outer root sheath (ORS) cells, and hair bulb cells in AGA mice. We then integrated network pharmacology and pilose antler transcriptomics data to predict that the mechanism of PAEs treatment in AGA mice is closely related to the PI3K-AKT/Wnt-β-Catenin pathways. Subsequently, it was also verified that PAEs could activate both pathways in the skin of AGA mice. In addition, we found that PAEs perhaps increased the number of blood vessels around dermal papilla (DP) in experiments in vivo. Meanwhile, the PAEs stimulated the HFSC proliferation in vitro and activated the AKT and Wnt pathways. However, the proliferative activity of HFSC was inhibited after blocking the Wnt pathway and AKT activity.Conclusion: This study suggests that the hair growth-promoting effect of PAEs in AGA mice may be closely related to the stimulation of the AKT and Wnt pathways, which in turn activates the proliferation of HFSC.

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Section: Introductionmentioning

confidence: 99%

Pilose antler extracts promotes hair growth in androgenetic alopecia mice by activating hair follicle stem cells via the AKT and Wnt pathways

Wang,

He,

Liu

et al. 2024

Front. Pharmacol.

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Deer antler extract-nanoparticles exhibit co-nanozyme activity and targeting of prostate cancer cells

Nazarbek,

Mu,

Shaimoldina

et al. 2024

Journal of Functional Foods

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Experimental studies of the safety of pantohematogen as a functional ingredient in specialized products: allergenic and immunotoxic properties

Dorn,

Lobach,

Guryanov

et al. 2024

Аграрная наука Евро-Северо-Востока

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The purpose of the research is to study the allergenic and immunotoxic properties of pantohematogen obtained from the blood of female Gorno-Altai maral deer as a functional ingredient of specialized products. Allergenic and immunotoxic properties were assessed in 2020–2022 by intragastric administration of pantohematogen to 395 CBA mice weighing 15–18 g, who received the drug at a therapeutic dose of 50 mg/kg and a maximum single dose of 500 mg/kg. The sensitization of the animal body after a course of administration of pantohematogen was determined by deregulation of mast cells. It has been established that when using the maximum single dose, the degranulation reaction does not exceed 0.2. It is necessary to emphasize that no changes in the leukocyte lysis coefficient were recorded in mice receiving different doses of pantohematogen. The effect of pantohematogen on the mass and cellularity of the immunocompetent organs of animals is also shown. It was noted that even the use of a dose (500 mg/kg) 10 times higher than the therapeutic dose does not affect the cellularity of immunocompetent organs. In general, the materials of experimental studies indicate the absence of allergenic and immunotoxic properties of the tested pantohematogen as a functional ingredient in the development of specialized products with specified therapeutic and prophylactic properties.

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Deer antler extract: Pharmacology, rehabilitation and sports medicine applications

Cited by 4 publications

References 106 publications

Pilose antler extracts promotes hair growth in androgenetic alopecia mice by activating hair follicle stem cells via the AKT and Wnt pathways

Pilose antler extracts promotes hair growth in androgenetic alopecia mice by activating hair follicle stem cells via the AKT and Wnt pathways

Deer antler extract-nanoparticles exhibit co-nanozyme activity and targeting of prostate cancer cells

Experimental studies of the safety of pantohematogen as a functional ingredient in specialized products: allergenic and immunotoxic properties

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