Deer antler – A novel model for studying organ regeneration in mammals

Li, Chunyi; Zhao, Haiping; Liu, Zhen; McMahon, Chris

doi:10.1016/j.biocel.2014.07.007

Cited by 112 publications

(93 citation statements)

References 71 publications

(97 reference statements)

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“…Very few mammals are documented as having the ability to regenerate tissue, the best known example is the regeneration of deer antlers each year, which is a form of epimorphic regeneration, whereby a regeneration blastema is formed composed mainly of mesenchymal cells derived from the pedicle periosteum and these cells then give rise to the new antlers which are composed of various cell types including skin, nerves, bone and blood vessels (Li et al, 2014). A lesser known example of mammalian regeneration, is the dolphin which has been documented to regenerate large lesions in the skin without scar formation (Bloom and M, 1994; Bruce-Allen and JR, 1985).…”

Section: Scar-free Regeneration: Learning From Animals With the Namentioning

confidence: 99%

Learning from regeneration research organisms: The circuitous road to scar free wound healing

Erickson

Echeverri

2018

Developmental Biology

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The skin is the largest organ in the body and plays multiple essential roles ranging from regulating temperature, preventing infection and ultimately defining who we are physically. It is a highly dynamic organ that constantly replaces the outermost cells throughout life. However, when faced with a major injury, human skin cannot restore a significant lesion to its original functionality, instead a reparative scar is formed. In contrast to this, many other species have the unique ability to regenerate full thickness skin without formation of scar tissue. Here we review recent advances in the field that shed light on how the skin cells in regenerative species react to injury to prevent scar formation versus scar forming humans.

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Section: Scar-free Regeneration: Learning From Animals With the Namentioning

confidence: 99%

Learning from regeneration research organisms: The circuitous road to scar free wound healing

Erickson

Echeverri

2018

Developmental Biology

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“…Since antlers are accessible, shed after mating season and cast every year, they appear to be a good model to study bone biology (Price et al 2005;Landete-Castilleijos et al 2007c;Li et al 2014b). Each antler grows from an attachment point on the skull called a pedicle.…”

Section: Antlersmentioning

confidence: 99%

Calcium orthophosphates (CaPO 4 ): Occurrence and properties

Dorozhkin¹

2017

Morphologie

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“…These processes, cellular dedifferentiation and blastema formation, are especially prominent in some animals with regenerative abilities, such as hydra (Galliot et al 2006;Bosch 2007a, b), planarians (Reddien and Sánchez Alvarado 2004), zebrafish (Poss et al 2003;Poss 2007), salamanders, axolotls and newts (Odelberg 2005;Brockes and Kumar 2005). There are also several reports on limited regeneration in mammals, including the regrowth of fingertips in mouse (Han et al 2008), antlers in deer (Li et al 2014), and ear hole closure in rabbit (Goss and Grimes 1975). The latter is one of the best examples of regeneration process in mammals, in which blastema tissue is formed on the periphery of the wound site (William-Boyce and Daniel 1980).…”

Section: Introductionmentioning

confidence: 99%

Blastema cells derived from New Zealand white rabbit’s pinna carry stemness properties as shown by differentiation into insulin producing, neural, and osteogenic lineages representing three embryonic germ layers

et al. 2014

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Stem cells (SCs) are known as undifferentiated cells with self-renewal and differentiation capacities. Regeneration is a phenomenon that occurs in a limited number of animals after injury, during which blastema tissue is formed. It has been hypothesized that upon injury, the dedifferentiation of surrounding tissues leads into the appearance of cells with SC characteristics. In present study, stem-like cells (SLCs) were obtained from regenerating tissue of New Zealand white rabbit's pinna and their stemness properties were examined by their capacity to differentiate toward insulin producing cells (IPCs), as well as neural and osteogenic lineages. Differentiation was induced by culture of SLCs in defined medium, and cell fates were monitored by specific staining, RT-PCR and flow cytometry assays. Our results revealed that dithizone positive cells, which represent IPCs, and islet-like structures appeared 1 week after induction of SLCs, and this observation was confirmed by the elevated expression of Ins, Pax6 and Glut4 at mRNA level. Furthermore, SLCs were able to express neural markers as early as 1 week after retinoic acid treatment. Finally, SLCs were able to differentiate into osteogenic lineage, as confirmed by Alizarin Red S staining and RT-PCR studies. In conclusion, SLCs, which could successfully differentiate into cells derived from all three germ layers, can be considered as a valuable model to study developmental biology and regenerative medicine.

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Deer antler – A novel model for studying organ regeneration in mammals

Cited by 112 publications

References 71 publications

Learning from regeneration research organisms: The circuitous road to scar free wound healing

Learning from regeneration research organisms: The circuitous road to scar free wound healing

Calcium orthophosphates (CaPO 4 ): Occurrence and properties

Blastema cells derived from New Zealand white rabbit’s pinna carry stemness properties as shown by differentiation into insulin producing, neural, and osteogenic lineages representing three embryonic germ layers

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