Deep Venous Thrombosis Prophylaxis by Low Molecular Weight Heparinin Neurosurgical Patients

Melon, E; Kéravel, Y.; Gaston, André; Huet, Y.; Combes, Stéphane

doi:10.1097/00000542-199109001-00214

Cited by 29 publications

(25 citation statements)

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“…One additional RCT was identified through manual searches of the reference lists of these 8 trials. 21 No additional RCTs were identified through a review of the Internet sources or conference proceedings ( Figure 1). …”

Section: Identification Of Eligible Studiesmentioning

confidence: 99%

“…Eight trials with 1441 patients (mean age, 52.4 years; 51.6% male) were initially identified. 13,[15][16][17][18][19][20][21] One additional unique trial by Bostrom et al 14 compared heparin and electric stimulation, and dextran was excluded. This trial from 1986 (Jadad score = 1; 104 patients) was disqualified from analysis because it did not isolate the effects of heparin for analysis purposes.…”

Section: Characteristics Of Eligible Studiesmentioning

confidence: 99%

“…13,[15][16][17][18]21 These were used to address our primary objective. Two trials compared LDUH and LMWH.…”

Section: Characteristics Of Eligible Studiesmentioning

confidence: 99%

See 2 more Smart Citations

Venous Thromboembolism Prophylaxis in Patients Undergoing Cranial Neurosurgery: A Systematic Review and Meta-analysis

Hamilton¹,

Yee²,

Hull³

et al. 2011

Neurosurgery

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Section: Identification Of Eligible Studiesmentioning

confidence: 99%

Section: Characteristics Of Eligible Studiesmentioning

confidence: 99%

See 1 more Smart Citation

Venous Thromboembolism Prophylaxis in Patients Undergoing Cranial Neurosurgery: A Systematic Review and Meta-analysis

Hamilton¹,

Yee²,

Hull³

et al. 2011

Neurosurgery

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“…For example, venography and I 125 fibrinogen were used to diagnose DVTs in 4 of the 6 trials, 2,11,13,34 tests that are not routinely used today, although they may be more sensitive than Doppler ultrasonography. Moreover, all patients underwent screening for DVT regardless of symptoms.…”

mentioning

confidence: 99%

Clinical factors associated with venous thromboembolism risk in patients undergoing craniotomy

Kimmell

Jahromi

2015

JNS

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The most recent meta-analysis of VTE prophylaxis in neurosurgical patients concluded abbreviatioNs ACS = American College of Surgeons; ASA = American Society of Anesthesiologists; BMI = body mass index; CI = confidence interval; CPT = current procedural terminology; DVT = deep venous thrombosis; MI = myocardial infarction; NSQIP = National Surgical Quality Improvement Program; OR = odds ratio; PE = pulmonary embolism; RCT = randomized controlled trial; SCIP = Surgical Care Improvement Project; TIA = transient ischemic attack; UTI = urinary tract infection; VTE = venous thromboembolism. submitted March 31, 2014. accepted October 22, 2014. iNclude wheN citiNg Published online December 12, 2014; DOI: 10.3171/2014.10.JNS14632. disclosure The authors report no conflict of interest concerning the materials or methods used in this study or the findings specified in this paper. Clinical factors associated with venous thromboembolism risk in patients undergoing craniotomyKristopher t. Kimmell, md, and babak s. Jahromi, md, phd Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York obJect Patients undergoing craniotomy are at risk for developing venous thromboembolism (VTE). The safety of anticoagulation in these patients is not clear. The authors sought to identify risk factors predictive of VTE in patients undergoing craniotomy. methods The authors reviewed a national surgical quality database, the American College of Surgeons National Surgical Quality Improvement Program. Craniotomy patients were identified by current procedural terminology code. Clinical factors were analyzed to identify associations with VTE. results Four thousand eight hundred forty-four adult patients who underwent craniotomy were identified. The rate of VTE in the cohort was 3.5%, including pulmonary embolism in 1.4% and deep venous thrombosis in 2.6%. A number of factors were found to be statistically significant in multivariate binary logistic regression analysis, including craniotomy for tumor, transfer from acute care hospital, age ≥ 60 years, dependent functional status, tumor involving the CNS, sepsis, emergency surgery, surgery time ≥ 4 hours, postoperative urinary tract infection, postoperative pneumonia, on ventilator ≥ 48 hours postoperatively, and return to the operating room. Patients were assigned a score based on how many of these factors they had (minimum score 0, maximum score 12). Increasing score was predictive of increased VTE incidence, as well as risk of mortality, and time from surgery to discharge. coNclusioNs Patients undergoing craniotomy are at low risk of developing VTE, but this risk is increased by preoperative medical comorbidities and postoperative complications. The presence of more of these clinical factors is associated with progressively increased VTE risk; patients possessing a VTE Risk Score of ≥ 5 had a greater than 20-fold increased risk of VTE compared with patients with a VTE score of 0.

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“…При хирургическом лечении онкологических заболеваний частота развития ВТ составляет 6,25-55,5% (в среднем 15,9%) на фоне применения анти коагулянтов и компрессионной терапии [26][27][28][29][30][31][32][33][34][35][36]. У больных нейрохирургического профиля на фоне применения механических, фармакологических средств профилактики и их комбинации частота ин струментальной верификации послеоперационных ВТ колеблется от 1,5 до 26,3% и в среднем составля ет 12,5% [37][38][39][40][41][42][43][44][45][46][47]. У пациентов отделения интенсив ной терапии на фоне соблюдения превентивных протоколов вероятность развития тромбоза коле блется от 5,5 до 33% (в среднем 12,0%) [48][49][50][51][52][53][54][55][56][57].…”

Section: флебология 1 2015unclassified

Toward the individual approach to the evaluation of risks and prevention of postoperative venous thromboembolism

Lobastov¹,

Barinov²,

Laberko³

2015

Flebol.

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Deep Venous Thrombosis Prophylaxis by Low Molecular Weight Heparinin Neurosurgical Patients

Cited by 29 publications

References 0 publications

Venous Thromboembolism Prophylaxis in Patients Undergoing Cranial Neurosurgery: A Systematic Review and Meta-analysis

Venous Thromboembolism Prophylaxis in Patients Undergoing Cranial Neurosurgery: A Systematic Review and Meta-analysis

Clinical factors associated with venous thromboembolism risk in patients undergoing craniotomy

Toward the individual approach to the evaluation of risks and prevention of postoperative venous thromboembolism

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