Deep Vein Thrombosis: Prevalence of Etiologic Factors and Results of Management in 100 Consecutive Patients

Epidemiology of Antiphospholipid Syndrome

“…Bick and colleagues [22] found, in 100 patients with venous thrombosis, that 24% had aCL and 4% had LA. In a study of 122 consecutive venous thrombotic patients, close to 15% had LA, aPL, or anti-␤ 2 GPI phospholipid.…”

Antiphospholipid-Thrombosis Syndromes

“…Incubation of the patient's plasma with normal plasma generally does not cause a sensitivity of the partial thromboplastin time to the inhibitor's effect, and one-stage assays for factors XII, XI, IX, and VII may yield low values when the standard dilutions of test plasma are used. Usually, further dilution of the test plasma causes the measured level of these factors to approach the normal range; an exception occurs in rare patients with decreased concentration of prothrombin resulting from accelerated removal of prothrombin antigen-antibody complexes [32,33].…”

“…Multiple LA assays are currently in use [32]. Sensitivity of the aPTT to the presence or absence of the LA is highly dependent on the reagents used.…”

Outcome Analysis for Treatment in 100 Patients with Deep Vein Thrombosis

“…One hundred consecutive patients were seen in consultation for DVT, and their cases were reported by Bick et al in 1992 (3). The etiologic factors and results of treatment were reviewed and summarized.…”

“…Independent studies of patients with DVT have noted that from 50% (34) to 55% (3) of cases may be related to a known risk factor. When a thorough investigation in search of these defects was performed, a blood defect of coagulation was found in 47% of the cases, 19% of them inherited (3,35).…”