Abstract:Background: Venous thromboembolism (VTE) can occur simultaneously with a cryptogenic stroke (CS) linked to patent foramen ovale (PFO), given paradox thromboembolism as potential stroke cause. However, little is known on the frequency of concomitant VTE and CS. We aimed to review the literature on the frequency of VTE in patients with CS linked to PFO (primary aim) and of ischemic stroke (IS) among patients with pulmonary embolism (PE) (secondary aim). Methods: We performed a Medline search for cohort studies, … Show more
“…23 Pulmonary embolism in stroke patients is an indicator of cryptogenic stroke. 24 Checking for patent foramen ovale and deep vein thrombosis is necessary in those patients given the possibility of additional embolic events.…”
Purpose In the majority of cases, large vessel occlusion (LVO) in ischemic stroke patients has an embolic origin. Systemic embolism can occur simultaneously with brain thrombosis. This retrospective study evaluated the frequency and locations of systemic embolism in LVO stroke patients receiving revascularization therapy. Materials and Methods In our facility, we use contrast-enhanced computed tomography (CE-CT) to assess suspected stroke patients and routinely perform CE-CT from the chest to the abdomen after brain CT angiography to rule out contraindications like aortic dissection and trauma for thrombolysis. Systemic embolism is also assessed using these images, while myocardial infarction is evaluated based on electrocardiograms and laboratory findings. Other relevant clinical features of each patient are also analyzed. Results In total, 612 consecutively admitted stroke patients and 32 LVO patients who underwent revascularization therapy were included in the present study. Systemic embolism was identified in four patients (13%). The spleen was the most commonly affected organ, followed by the heart, kidneys, limbs, and lungs. All four patients with systemic embolism exhibited LVO resulting from embolism as the underlying mechanism. Conclusion Systemic embolism was observed in 13% of our LVO patients, all of whom had LVO of embolic origin.
“…23 Pulmonary embolism in stroke patients is an indicator of cryptogenic stroke. 24 Checking for patent foramen ovale and deep vein thrombosis is necessary in those patients given the possibility of additional embolic events.…”
Purpose In the majority of cases, large vessel occlusion (LVO) in ischemic stroke patients has an embolic origin. Systemic embolism can occur simultaneously with brain thrombosis. This retrospective study evaluated the frequency and locations of systemic embolism in LVO stroke patients receiving revascularization therapy. Materials and Methods In our facility, we use contrast-enhanced computed tomography (CE-CT) to assess suspected stroke patients and routinely perform CE-CT from the chest to the abdomen after brain CT angiography to rule out contraindications like aortic dissection and trauma for thrombolysis. Systemic embolism is also assessed using these images, while myocardial infarction is evaluated based on electrocardiograms and laboratory findings. Other relevant clinical features of each patient are also analyzed. Results In total, 612 consecutively admitted stroke patients and 32 LVO patients who underwent revascularization therapy were included in the present study. Systemic embolism was identified in four patients (13%). The spleen was the most commonly affected organ, followed by the heart, kidneys, limbs, and lungs. All four patients with systemic embolism exhibited LVO resulting from embolism as the underlying mechanism. Conclusion Systemic embolism was observed in 13% of our LVO patients, all of whom had LVO of embolic origin.
“…In this condition, there is considerable evidence suggesting that PFO is highly associated with renal artery embolism, and PFO detection is very important and necessary. There are some cases of cryptogenic stroke with PFO and PTE [ 28 , 29 , 30 , 31 ], but little cases with renal artery embolism and renal infarction [ 32 , 33 ]. In this case, there was a renal artery embolism and infarction, and there is no evidence of coagulopathy, which can cause the systematic embolism.…”
We report a singular case of renal embolism in a hitherto healthy 46-year-old female. The patient initially presented with symptoms of exertional distress and chest discomfort. Following an extensive diagnostic workup, she was subsequently diagnosed with acute pulmonary embolism. On the day succeeding her admission, the patient manifested sustained abdominal discomfort. Abdominal computed tomography angiography (CTA) subsequently revealed the presence of renal artery embolisms and infarctions. Concurrently, an echocardiographic evaluation disclosed a patent foramen ovale (PFO) and pulmonary hypertension. In this specific case, we hypothesize that the embolic event traversed through the PFO, ultimately localizing in the renal artery and culminating in renal embolism.
“…Deep venous thrombosis (DVT) is also associated with PFO and may contribute to paradoxical embolism leading to CS. 11 Retrospective data show an incidence as high as 20% of contaminant DVT in patients with CS and PFO. 11 Work-up for CS should include imaging to evaluate for DVT.…”
Section: Ttementioning
confidence: 98%
“…11 Retrospective data show an incidence as high as 20% of contaminant DVT in patients with CS and PFO. 11 Work-up for CS should include imaging to evaluate for DVT.…”
Cryptogenic stroke (CS) represents one-third of all ischaemic strokes. Studies have shown approximately that half of patients with CS have concomitant patent foramen ovale (PFO), with clear data supporting paradoxical embolization as an aetiology of CS. This article is the first of a multi-part review and will detail the history of PFO closure and the clinical trials that have evaluated the efficacy of PFO device closure. Data favour PFO closure in CS for reducing stroke in appropriate patients and should be considered as a treatment modality.
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