Deep Vein Thrombosis and Pulmonary Embolism: The Same Disease?

Monréal, Manuel; Barba, Raquel; Tolosa, Carles; Tiberio, G; Todolí, José; Sampériz, A.

doi:10.1159/000093555

Cited by 20 publications

(22 citation statements)

References 6 publications

(5 reference statements)

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“…Several studies have shown that a number of patients with symptomatic DVT possess silent PE whereas asymptomatic DVT might be present in many patients with PE [11]. However, the exact prevalence of DVT in patients with PE and the clinical significance of concomitant DVT are vastly unknown [12–14].…”

Section: Introductionmentioning

confidence: 99%

Deep Vein Thrombosis in Patients with Pulmonary Embolism: Prevalance, Clinical Significance and Outcome

Lee

Moon

Kim

et al. 2016

VSI

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Purpose:Deep venous thrombosis (DVT) and pulmonary embolism (PE) are considered as similar disease entities representing different clinical manifestations. The objectives of this study were: 1) to determine the prevalence and outcome of DVT in patients with PE; 2) to identify additional risk factors for PE-related unfavorable outcome and 30-day all-cause mortality; and 3) to establish the clinical importance of screening for concomitant DVT.Materials and Methods:From January 2013 to December 2015, a total of 141 patients with confirmed PE were evaluated. The prevalence and outcome of DVT in patients with PE was determined. Furthermore, the potential risk factors for PE-related unfavorable outcome and 30-day all-cause mortality were also analyzed.Results:The prevalence of concomitant DVT was 45.4%. PE-related unfavorable outcome was observed in 21.9% of all concomitant DVT, with all-cause mortality of 21.9%. There was no significant relationship between the presence of concomitant DVT and the development of PE-related unfavorable outcome or all-cause mortality. Our results indicated that heart rate >100/min and peripheral oxygen saturation <90% were independent predictors for PE-related unfavorable outcome. Regarding all-cause mortality, active malignancy and hypotension or shock were significant risk factors.Conclusion:Our findings demonstrate that approximately half of patients with PE possess DVT. However, this study failed to establish any clinical significance of concomitant DVT for PE-related unfavorable outcome and all-cause mortality. Tachycardia and hypoxemia were identified as significant predictors for PE-related unfavorable outcome along with active malignancy and hypotension or shock as significant risk factors of all-cause mortality.

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Section: Introductionmentioning

confidence: 99%

Deep Vein Thrombosis in Patients with Pulmonary Embolism: Prevalance, Clinical Significance and Outcome

Lee

Moon

Kim

et al. 2016

VSI

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“…DVT is characterized by the formation of an occlusive blood clot in the venous vascular system, which can potentially result in PE, due to detachment and embolization of thrombi into the lung. Therefore, DVT and PE are regarded as two different stages of the same disease, and are associated with common risk factors caused by genetic, environmental and behavioral interactions (2,3). DVT is a major cause of cardiovascular-associated mortality and its treatment is limited to palliation, including mechanical leg compression and anticoagulation therapy (4).…”

Section: Introductionmentioning

confidence: 99%

Platelet endothelial cell adhesion molecule-1 gene 125C/G polymorphism is associated with deep vein thrombosis

Han

Dong

et al. 2015

Molecular Medicine Reports

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Deep vein thrombosis (DVT) is a common disorder that is associated with high morbidity and mortality. Genetic factors have been suggested to influence the predisposition towards thrombosis and the incidence of DVT. Platelet endothelial cell adhesion molecule-1 (PECAM-1) is a key adhesion molecule that is involved in platelet function and maintenance of endothelial cell junctions. To date, no studies have examined the association between polymorphisms in PECAM-1 and DVT. The present study analyzed the single nucleotide polymorphisms (SNPs) of PECAM-1, namely Leu125Val (C373G), Asn563Ser (T1688C) and Gly670Arg (C2008T), in Chinese patients with DVT and age-and gender-matched controls, using polymerase chain reaction-restriction fragment length polymorphism analysis. Furthermore, plasma soluble PECAM-1 (sPECAM-1) levels were quantified by ELISA. The results of the present study demonstrated significantly higher genotype and allele frequencies of the Leu125Val polymorphism in PECAM-1 in the DVT group as compared with those in the control group (P<0.05). The plasma levels of sPECAM-1 in the DVT group (83.4 ± 23.5 ng/ml) were also significantly higher as compared with those in the control group (60.4 ± 19.4 ng/ml, P<0.01). In the patients with DVT, plasma levels of sPECAM-1 were significantly higher in those with the Leu/Val and Val/Val genotypes as compared with those possessing the Leu/Leu genotype (P<0.05). The PECAM-1 Leu125Val polymorphism was shown to be associated with an increased risk of DVT and PECAM-1 protein expression levels in venous vessels. In patients with DVT, the PECAM-1 Leu/Val and Val/Val genotypes were associated with delayed thrombus resolution, as determined by thrombus scoring, as compared with that in patients possessing the Leu/Val genotype. In conclusion, the present study indicated that PECAM-1 Leu125Val polymorphism and sPECAM-1 levels may be associated with DVT.

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“…On the other hand, we have selected patients with initial DVT, excluding patients with symptomatic PE. Although DVT and PE have been traditionally considered as clinical manifestations of the same disease, several studies have pointed out relevant differences between them regarding physiopathology, management, and outcomes (4,28,29). In addition, in a preliminary study we found that gene expression profile was notably different between patients with initial DVT or PE (data not shown).…”

Section: Discussionmentioning

confidence: 99%

Identification of new markers of recurrence in patients with unprovoked deep vein thrombosis by gene expression profiling: the retro study

Montes¹,

Guruceaga²,

González‐Porras

et al. 2015

European J of Haematology

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Deep Vein Thrombosis and Pulmonary Embolism: The Same Disease?

Cited by 20 publications

References 6 publications

Deep Vein Thrombosis in Patients with Pulmonary Embolism: Prevalance, Clinical Significance and Outcome

Deep Vein Thrombosis in Patients with Pulmonary Embolism: Prevalance, Clinical Significance and Outcome

Platelet endothelial cell adhesion molecule-1 gene 125C/G polymorphism is associated with deep vein thrombosis

Identification of new markers of recurrence in patients with unprovoked deep vein thrombosis by gene expression profiling: the retro study

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