Deep Vein Thrombosis and Changes in Coagulation and Fibrinolysis after Gynaecological Operations in Chinese: the Effect of Oral Contraceptives and Malignant Disease

Tso, S. C.; Wong, Vivian Taam; Chan, Vivian; Chan, TK; K., H.; Todd, D.

doi:10.1111/j.1365-2141.1980.tb06018.x

Cited by 59 publications

(50 citation statements)

References 27 publications

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“…Crossed immunoelectrophoresis of AT III in plasma and serum showed changes following surgery. A decrease of these inhibitors fol lowing major surgical procedures has been previously described by several authors [25][26][27], Our results are consistent with those described by Gitel et al [28] and Gray et al [29], both of whom found no alterations in AT III levels after total hip replacement. With respect to the alterations found in crossed electrophoresis of AT III it has been suggested by several authors that they could be due to AT III complexes with thrombin and other serine proteases [30][31][32].…”

Section: Discussionsupporting

confidence: 83%

“…A sig nificant postoperative increase in the concen trations of fibrinogen, factor VI1I:C and fac tor VIIIR:Ag was present, while factor Xa levels and electrophoretic mobility of factor VIII remained unchanged. Similar results were reported by Houghton et al [24] after total hip replacement, and by Tso et al [25] following gynecological procedures. No alter ations were found in the mean concentration of AT III and antifactor Xa in our series.…”

Section: Discussionsupporting

confidence: 81%

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Changes in Coagulation and Fibrinolysis after Total Hip Replacement and Their Relations with Deep Vein Thrombosis

Paramo¹,

Rocha²

1985

Pathophysiol Haemos Thromb

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Postoperative changes related to coagulation and fibrinolysis and their correlation with the incidence of deep venous thrombosis (DVT) were studied in 30 patients undergoing total hip replacement. Pre- and postoperative measurements of fibrinogen, factor Xa, VIIl·C, VIΠR:Ag and its electrophoretic mobility, antifactor Xa activity, antithrombin III (AT III) and its electrophoretic mobility in plasma and serum, fibrin monomers, euglobulin lysis time, fibrinogen degradation products (FDP), α₂-antiplasmin and plasmin-antiplasmin complexes were determined. DVT was detected by ¹²⁵I-fibrinogen leg scanning in 11 patients. There was a significant and progressive increase in fibrinogen, VIII:C, VIIIR:Ag, fibrin monomers, FDP and α₂-antiplasmin levels after operation and likewise a prolongation of euglobulin lysis time. There were changes in electrophoretic mobility of AT III in plasma and serum in 12 patients. The presence of plasmin-antiplasmin complexes was demonstrated in 9 patients. No correlation between the changes in coagulation and fibrinolysis and the incidence of postoperative DVT was found. We conclude that important changes occur in several parameters of coagulation and fibrinolysis after total hip replacement. Such changes are not related to the development of postoperative DVT.

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Section: Discussionsupporting

confidence: 83%

Section: Discussionsupporting

confidence: 81%

Changes in Coagulation and Fibrinolysis after Total Hip Replacement and Their Relations with Deep Vein Thrombosis

Paramo¹,

Rocha²

1985

Pathophysiol Haemos Thromb

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“…According to some ethnic-comparison studies, the incidence among Asian-Americans and Asian-Pacific Islanders appears to be 2.5-fold to 4-fold lower than that among Caucasians [8][9][10]. Symptomatic VTE after surgery has been found to be rare in studies from East Asia [11,12]. Thus, we hypothesized that the incidence and recurrence rate of VTE may be lower in the Taiwanese population than in Caucasians.…”

Section: Introductionmentioning

confidence: 99%

Incidence and cumulative recurrence rates of venous thromboembolism in the Taiwanese population

Lee

Lin

Cheng

et al. 2010

Journal of Thrombosis and Haemostasis

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Summary. Background: Little information is available on the epidemiology of venous thromboembolism (VTE) in Asian populations. Objectives: To investigate VTE incidence, VTE cumulative recurrence rates and risk factors for VTE recurrence among the adult Taiwanese population. Methods: This population-based cohort study used the Taiwanese National Health Insurance claims databases to identify 5347 adult patients (2463 men, 46.1%) with VTE diagnosed in 2001 and 2002. We calculated the crude incidence of VTE and its recurrence. We also conducted a nested case-control study (n = 3576) among this population to estimate the association between VTE recurrence and exposure to potential VTE risk factors by conditional logistic regression. Results: The crude incidence of VTE was 15.9 per 100 000 person-years, and its recurrence rate was 5.1% per person-year. During 11 566 person-years of follow-up, the cumulative rates of VTE recurrence at 6, 12, 24, 36 and 47 months were 6.7%, 9.4%, 12.4%, 13.9%, and 14.4%, respectively. By conditional logistic regression, histories of VTE [adjusted odds ratio (OR) 1.71, 95% confidence interval (CI) 1.32-2.16] or malignant neoplasm (adjusted OR 1.64, 95% CI 1.26-1.99), major extremity trauma (adjusted OR 2.76, 95% CI 1.82-4.52), serious neurologic diseases (adjusted OR 1.43, 95% CI 1.12-1.84) or undergoing major surgery (adjusted OR 4.57, were associated with higher risks of VTE recurrence. Conclusions: The incidence of VTE is lower in the Taiwanese population than in Caucasians. Most VTE recurrences occur within 12 months, but they continue to occur beyond 1 year. The VTE recurrences are associated with malignancy, history of VTE, and major surgery after a previous VTE.

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“…Venous thromboembolism (VTE) has been considered rare among Chinese [1,2], but recent studies have showed an increasing trend [3,4]. The reason for its increased trend in the Chinese population remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Thrombophilia among Chinese Women with Venous Thromboembolism during Pregnancy

Tam

Ng²,

Yiu

et al. 2012

Gynecol Obstet Invest

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Aims: To assess the prevalence of thrombophilia among Chinese women with venous thromboembolism (VTE) developed during pregnancy. Methods: Based on information from a tertiary teaching unit, all recorded cases of deep vein thrombosis (DVT) and pulmonary embolism (PE) during pregnancy diagnosed between 1997 and 2005, were assessed for prevalence of thrombophilia. Fifty-five healthy women, who had at least one normal pregnancy but without any previous history of VTE, were recruited as controls. Results: A total of 44 subjects completed thrombophilia screening, of whom 5 (11%) were confirmed to have thrombophilia [protein C (PC) deficiency (2), protein S (PS) deficiency (1), combined PC & PS deficiency (1) and antithrombin III deficiency (1)]. Homozygous 5,10-methylenetetrahydrofolate reductase (C677T) gene mutation was found in 6 (14%) subjects but not in the controls. There was no antiphospholipid syndrome, activated PC resistance, factor V Leiden or prothrombin gene mutations. Conclusion: In the Chinese population, PS and PC deficiencies are common thrombophilia for VTE during pregnancy and thrombophilia screening should be recommended in all pregnant women who suffer from VTE.

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Deep Vein Thrombosis and Changes in Coagulation and Fibrinolysis after Gynaecological Operations in Chinese: the Effect of Oral Contraceptives and Malignant Disease

Cited by 59 publications

References 27 publications

Changes in Coagulation and Fibrinolysis after Total Hip Replacement and Their Relations with Deep Vein Thrombosis

Changes in Coagulation and Fibrinolysis after Total Hip Replacement and Their Relations with Deep Vein Thrombosis

Incidence and cumulative recurrence rates of venous thromboembolism in the Taiwanese population

Thrombophilia among Chinese Women with Venous Thromboembolism during Pregnancy

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