Deep‐targeted gene sequencing reveals ARID1A mutation as an important driver of glioblastoma
Menglin Xiao,
Xiaoteng Cui,
Can Xu
et al.
Abstract:AimsTo investigate the key factors influencing glioma progression and the emergence of treatment resistance by examining the intrinsic connection between mutations in DNA damage and repair‐related genes and the development of chemoresistance in gliomas.MethodsWe conducted a comprehensive analysis of deep‐targeted gene sequencing data from 228 glioma samples. This involved identifying differentially mutated genes across various glioma grades, assessing their functions, and employing I‐TASSER for homology modeli… Show more
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