“…The selection of patients with advanced (T3, T4) resectable laryngeal cancers for definitive radiotherapy based on favorable prognostic characteristics has resulted in reports with local control rates comparable to those reported in surgical series [25][26][27]. Unfavorable characteristics for definitive radiotherapy include soft tissue invasion [28], cartilage invasion [25,28,29], the need for tracheotomy [25,30,31], extension into the hypopharynx [32], extensive involvement of the preepiglottic space [26,33], infiltrative rather than exophytic growth [34][35][36][37], extension into the oropharynx, and base of tongue involvement [26]. Most of these characteristics directly reflect the tumor volume.…”