Deep skin wound healing potential of lavender essential oil and licorice extract in a nanoemulsion form: Biochemical, histopathological and gene expression evidences

Kazemi, Maryam; Mohammadifar, Mojgan; Aghadavoud, Esmat; Vakili, Zarichehr; Aarabi, Mohammad Hossein; Talaei, Sayyed Alireza

doi:10.1016/j.jtv.2020.03.004

Cited by 51 publications

(29 citation statements)

References 21 publications

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“…The detail score criteria included the regeneration of epithelial tissues, inflammatory cell infiltration, angiogenesis, and the thickness of the granulation; scores from 0 to 3 indicated from lack of recovery to full recovery. The four variables were summed to represent the histopathological score (total score: 0-12, respectively) (Kazemi et al, 2020).…”

Section: Histopathological Evaluation and Type I Collagen Staining Onmentioning

confidence: 99%

Burn Ointment Promotes Cutaneous Wound Healing by Modulating the PI3K/AKT/mTOR Signaling Pathway

Gan

et al. 2021

Front. Pharmacol.

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Burn ointment (BO) is a clinically useful medicine for the treatment of burns and scalds. However, there is no enough scientific evidence to report the effect of BO on wound healing and its analgesic and anti-inflammatory efficacy. The aim of this work was to evaluate the anti-inflammatory and analgesic efficacy of BO and to reveal the potential wound healing properties and related mechanisms of BO. In this work, the content of active ingredients of BO was determined by high-performance liquid chromatography (HPLC). Two animal models of inflammation were used to study its anti-inflammatory activity, and a hot plate method was used to evaluate its analgesic effect. In addition, mouse incision and rat burn models were used to investigate the effect of BO on the anti-inflammatory and wound healing mechanisms. The results showed that BO was safe for topical application, and BO could significantly inhibit auricular swelling in mice and paw swelling in rats and significantly prolong the latency period of paw licking in the hot plate experiment in mice. It can also accelerate wound healing and repair scars by promoting the formation of new epithelial tissues in rat burn models. In addition, BO significantly downregulated the serum level of TNF-α and significantly increased the serum levels of VEGF and TGF-β1. Also, BO promoted the expression of collagen I and increased the ratio in p-PI3K/PI3K, p-AKT/AKT, and p-mTOR/mTOR pathways. Our results demonstrate the safety and efficacy of BO and suggest that activation of the PI3K/AKT/mTOR signaling pathway may play an important role in the promotion of wound healing by BO.

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Section: Histopathological Evaluation and Type I Collagen Staining Onmentioning

confidence: 99%

Burn Ointment Promotes Cutaneous Wound Healing by Modulating the PI3K/AKT/mTOR Signaling Pathway

Gan

et al. 2021

Front. Pharmacol.

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“…Prepared nanoemulsion has antioxidant properties, which is very essential in anti-cancer activity as well. Figure 4 depicts the formulation and evaluation of nanoemulsion of lavender essential oil and licorice extract and their promising results to be used for dermal delivery [108].…”

Section: (Iii) Transferosomesmentioning

confidence: 99%

Skin cancer therapeutics: nano-drug delivery vectors—present and beyond

et al. 2021

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Background Skin cancers are among the widely prevalent forms of cancer worldwide. The increasing industrialization and accompanied environmental changes have further worsened the skin cancer statistics. The stern topical barrier although difficult to breach is a little compromised in pathologies like skin cancer. The therapeutic management of skin cancers has moved beyond chemotherapy and surgery. Main body of the abstract The quest for a magic bullet still prevails, but topical drug delivery has emerged as a perfect modality for localized self-application with minimal systemic ingress for the management of skin cancers. Advances in topical drug delivery as evidenced by the exploration of nanocarriers and newer technologies like microneedle-assisted/mediated therapeutics have revolutionized the paradigms of topical treatment. The engineered nanovectors have not only been given the liberty to experiment with a wide-array of drug carriers with very distinguishing characteristics but also endowed them with target specificity. The biologicals like nucleic acid-based approaches or skin penetrating peptide vectors are another promising area of skin cancer therapeutics which has demonstrated potential in research studies. In this review, a panoramic view is presented on the etiology, therapeutic options, and emerging drug delivery modalities for skin cancer. Short conclusion Nanocarriers have presented innumerable opportunities for interventions in skin cancer therapeutics. Challenge persists for the bench to bedside translation of these highly potential upcoming therapeutic strategies. Graphic abstract

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“…Kazemi et al [ 73 ] used the spontaneous emulsification method to prepare a nano-emulsion for wound treatment with lavender essential oil and licorice extract. Treatment with the nano-emulsion increased the expression of transforming growth factor-β (TGF-β), increased the expressions of type I and type III collagen genes, accelerated the formation of granular tissue and collagen, reduced the degree of lipid peroxidation, and increased the activities of superoxide dismutase (SOD) and glutathione peroxidase (GPx).…”

Section: Lipid-based Delivery Systems In Regenerative Medicinementioning

confidence: 99%

Lipid-Based Drug Delivery Systems in Regenerative Medicine

Filipczak

Yalamarty

et al. 2021

Materials

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The most important goal of regenerative medicine is to repair, restore, and regenerate tissues and organs that have been damaged as a result of an injury, congenital defect or disease, as well as reversing the aging process of the body by utilizing its natural healing potential. Regenerative medicine utilizes products of cell therapy, as well as biomedical or tissue engineering, and is a huge field for development. In regenerative medicine, stem cells and growth factor are mainly used; thus, innovative drug delivery technologies are being studied for improved delivery. Drug delivery systems offer the protection of therapeutic proteins and peptides against proteolytic degradation where controlled delivery is achievable. Similarly, the delivery systems in combination with stem cells offer improvement of cell survival, differentiation, and engraftment. The present review summarizes the significance of biomaterials in tissue engineering and the importance of colloidal drug delivery systems in providing cells with a local environment that enables them to proliferate and differentiate efficiently, resulting in successful tissue regeneration.

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Deep skin wound healing potential of lavender essential oil and licorice extract in a nanoemulsion form: Biochemical, histopathological and gene expression evidences

Cited by 51 publications

References 21 publications

Burn Ointment Promotes Cutaneous Wound Healing by Modulating the PI3K/AKT/mTOR Signaling Pathway

Burn Ointment Promotes Cutaneous Wound Healing by Modulating the PI3K/AKT/mTOR Signaling Pathway

Skin cancer therapeutics: nano-drug delivery vectors—present and beyond

Lipid-Based Drug Delivery Systems in Regenerative Medicine

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