Deep sequencing analysis of clinical samples from patients with acute infectious conjunctivitis during the COVID-19 delta surge in Madurai, India

Lalitha, Prajna; Prajna, Namperumalsamy Venkatesh; Rameshkumar, Gunasekaran; Teja, Gonugunta Vishnu; Sharma, Sankalp S.; Hinterwirth, Armin; Ruder, Kevin; Zhong, Lina; Chen, Cindi; Deiner, Michael; Huang, ChunHong; Pinsky, Benjamin A.; Lietman, Thomas M.; Doan, Thuy; Seitzman, Gerami D.

doi:10.1016/j.jcv.2022.105318

Cited by 11 publications

(6 citation statements)

References 14 publications

(12 reference statements)

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“…Using primers specific to the hexon region, this study confirmed the presence of HAdV type 8 from Group D in an ocular swab specimen. (Figure .1) Prior research conducted in India found that 78.6% of people in Pune and 100% in Pondicherry were affected by type 8 [16,17].…”

Section: Figure 1: Neighbor-joining Bootstrap Consensus Phylogenetic ...mentioning

confidence: 96%

Adenoviral Conjunctivitis in the Andaman Islands: A Clinical and Molecular Epidemiological Study

Beniwal,

Parvez,

Saharan

et al. 2023

Cureus

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Human adenoviruses are common causes of many acute illnesses, and keratoconjunctivitis is one of them. Acute infections, if left untreated, can progress to severity, thus causing morbidities and mortalities. It belongs to the mastadenovirus family and is characterized by seven subgenus, i.e., A-G; among those, Adenovirus D8 is the most common type associated with keratoconjunctivitis. MethodologyA hospital-based study was conducted, and the samples were collected from GB Pant Hospital, Port Blair, Dr Agarwals Eye Hospital, Port Blair, from August 2017 to December 2022. Clinical data and demographic details were followed by conjunctival swab sample collection from suspected keratoconjunctivitis patients. Samples were subjected to molecular screening, and Sanger sequencing was carried out for positive samples. ResultsOut of 506 conjunctival samples, a prevalence of 24.9% (n=126) was observed, and the commonest type circulating among the population of Andaman was Adenovirus D8. The major symptoms associated were eye redness (87.30%, n=110), followed by watering (81.75%, n=103), eye pain (72.22%, n=91), eye itching (61.11%, n=77), and discharge (50%, n=63). ConclusionIn clinical research, ocular infections are one of the underrated fields. However, the study revealed the high prevalence of adenoviral infection among the suspected patients. Thus, there is a need for proper surveillance and timely diagnosis of such infections, as their severity may lead to loss of vision.

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Section: Figure 1: Neighbor-joining Bootstrap Consensus Phylogenetic ...mentioning

confidence: 96%

Adenoviral Conjunctivitis in the Andaman Islands: A Clinical and Molecular Epidemiological Study

Beniwal,

Parvez,

Saharan

et al. 2023

Cureus

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“…Another study conducted at Aravind Eye Center in Madurai, India showed the association between conjunctivitis and covid in almost 11% of the patients. Along with conjunctival scarring covid can also cause optic neuritis, uveitis, and keratitis [43][44][45][46] .…”

Section: Conjunctivitis Association With Covidmentioning

confidence: 99%

Development in therapeutic strategies for allergic conjunctivitis

Singh,

Mazumder,

Monika

et al. 2023

Trends Immunother

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Conjunctivitis, also known as pink eye, is a conjunctival inflammation. It is brought on by bacteria, viruses, toxins, and allergies, including coronaviruses, the most frequent reason being allergic conjunctivitis (AC), which is brought on by exposure to pollutants like pollen, animal hair, or mold. The primary contributor to it is the linkage of immunoglobulin E caused by allergens and receptors on stimulated conjunctival mast cells. As a consequence, mast cells are degranulated, along with the release of histamine, cytokines, chemokines, and lipid mediators. The particular eye tissues impacted and the immune mechanism(s) (both local and systemic) that are involved all play a role in the clinical course, length, intensity, and co-morbidities. It frequently occurs in conjunction with allergic rhinitis, also known as allergic rhino-conjunctivitis and other allergy conditions. Atopic keratoconjunctivitis, giant papillary conjunctivitis, seasonal and perennial conjunctivitis, and vernal keratoconjunctivitis are the different types of allergic conjunctivitis. Ocular allergies are frequently misdiagnosed and undertreated, despite the emergence of innovative therapeutic strategies. This review focuses on several previously published studies to discuss the available therapeutic options for treating allergic conjunctivitis as well as the potential targets for the therapies. The association of conjunctivitis with COVID-19, along with recent patents and research, has also been explored.

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“…Em nossos resultados, as características ou sintomas mais comuns foram; epífora que oscilou entre 15% e 86% (Lalitha et al, 2022;Prajna et al, 2022;Ranzenigo et al, 2021), seguida de corpo estranho que atingiu entre 11,8% e 57,1% (Almazroa et al, 2022;Jin et al, 2021;Panoutsopoulos, 2020), secreção de 26,8% a 38,5% (Aggarwal et al, 2020;Jin et al, 2021;Prajna et al, 2022), coceira de 46% para 71% (Lalitha et al, 2022;Prajna et al, 2022), dor ocular que foi de 11,2% para 31,2% % (Aggarwal et al, 2020;Lalitha et al, 2022;Ranzenigo et al, 2021), hiperemia de 11,2% para 26,8% (Aggarwal et al, 2020;Binotti & Hamrah, 2022;Layikh et al, 2021;Mocanu et al, 2022;Ranzenigo et al, 2021), olho seco de 9,8% a 33,3% (Almazroa et al, 2022;Inomata et al, 2020), olho pegajoso com 10% (Ranzenigo et al, 2021), congestão conjuntival entre 5,0% a 28,8% % (Binotti & Hamrah, 2022;Chen et al, 2020;Jin et al, 2021;Layikh et al, 2021), visão turva que chegou a 12,7%…”

Section: Métodounclassified

Conjuntivite como manifestação oftalmológica de SARS-CoV-2 em indivíduos com Covid-19

Aucay¹,

González²,

Anaya³

et al. 2023

Braz. J. Hea. Rev.

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Objetivo: descrever as características da conjuntivite como manifestação oftalmológica do SARS-CoV-2 em indivíduos com COVID-19. Método: foi realizada uma revisão integrativa de artigos publicados entre 2020 e 2022, utilizando a estratégia PICO para integrar a questão de pesquisa. As buscas eletrônicas foram realizadas nas bases de dados Pubmed (https://pubmed.ncbi.nlm.nih.gov/) e ScienceDirect (https://www.sciencedirect.com/), em espanhol ou inglês, usando descritores e operadores booleanos AND e OR. Foi realizada uma busca eletrônica para descrever as características da conjuntivite como manifestação oftalmológica do SARS-CoV-2 em indivíduos com COVID-19. Resultados: Foi identificado um registro total de 96 artigos, incluindo 14 estudos de pacientes que manifestaram conjuntivite por SARS-CoV-2 como manifestação de COVID-19. A conjuntivite como manifestação oftalmológica do SARS-CoV-2 em indivíduos com COVID-19 apresenta prevalência de 0,8% a 31,6%. As características mais comuns são; hiperemia conjuntival, epífora, sensação de corpo estranho e fotofobia. Conclusão: A conjuntivite pode ser uma parte inicial do quadro clínico da COVID-19, ou pode até se manifestar como o único sintoma que aparece dias antes, a incidência e as características da conjuntivite como manifestação oftalmológica da COVID-19 são variáveis.

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Deep sequencing analysis of clinical samples from patients with acute infectious conjunctivitis during the COVID-19 delta surge in Madurai, India

Cited by 11 publications

References 14 publications

Adenoviral Conjunctivitis in the Andaman Islands: A Clinical and Molecular Epidemiological Study

Adenoviral Conjunctivitis in the Andaman Islands: A Clinical and Molecular Epidemiological Study

Development in therapeutic strategies for allergic conjunctivitis

Conjuntivite como manifestação oftalmológica de SARS-CoV-2 em indivíduos com Covid-19

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