Deep sedation with midazolam and propofol in children undergoing ambulatory magnetic resonance imaging of the brain

Jevdjić, Jasna; Šurbatović, Maja; Drakulic-Miletic, Svetlana; Zunic, Filip

doi:10.2298/vsp1110842j

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…In addition, concomitant administration of propofol with midazolam brings drug synergy effect on sedation and contributes to decreased risk of having adverse events [ 4 , 6 ]. Therefore, by using midazolam and propofol combination regimen, it could provide short induction time, fast recovery, stable cardiorespiratory conditions, and rarely requires additional sedation, and therefore is safe and adequate for pediatric MRI sedation [ 6 , 12 ]. However, midazolam has longer induction and recovery times than propofol, these disadvantages are less severe than those seen with dexmedetomidine [ 10 , 11 ].…”

Section: Discussionmentioning

confidence: 99%

A comparison of the use of propofol alone and propofol with midazolam for pediatric magnetic resonance imaging sedation – a retrospective cohort study

et al. 2017

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BackgroundPediatric MRI sedation performed by a variety of specialists such as sedationists and anesthesiologists commonly uses propofol, which has similar effects to an ideal sedative agent for maintaining deep sedation. However, when propofol is used, adverse airway events are relatively more common than when using other sedative agents. The concomitant administration of midazolam and propofol can reduce the dose of propofol needed for adequate sedation and might also reduce the frequency of airway obstruction without affecting the patient’s recovery profile.MethodsWe reviewed the our hospital records of all pediatric MRI sedation patients aged 3 to 16 years who were sedated with either propofol alone or propofol with midazolam between December 2013 and June 2016.ResultsEight hundred ninety-seven pediatric MRI sedation patients were included (n = 897). The frequency of airway intervention was 25/356 (7.0%) in Group P and 15/541 (2.8%) in Group PM (difference in proportions: 4.2%; 95% CI: 1.4–7.6%; p = 0.002). The mean (SD) time to awake was longer in Group PM compared to Group P [21.2 (5.6) minutes vs. 23.0 (7.1) minutes; mean difference, 1.8 min; 95% CI, 0.9–2.9; p < 0.001]. The mean (SD) time to discharge was longer in Group PM compared to Group P [34.5 (6.9) minutes vs. 38.6 (9.4) minutes; mean difference, 4.0 min; 95% CI, 3.0–5.1; p < 0.001].ConclusionsThe administration of a small dose of midazolam during pediatric MRI sedation using propofol can reduce the frequency of airway complications without prolonging the clinically significant recovery profile.

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Section: Discussionmentioning

confidence: 99%

A comparison of the use of propofol alone and propofol with midazolam for pediatric magnetic resonance imaging sedation – a retrospective cohort study

et al. 2017

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Comparison of Midazolam and Propofol for Sedation in Pediatric Diagnostic Imaging Studies

Sebe

Yılmaz

Köseoğlu

et al. 2014

Postgraduate Medicine

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Propofol seems to be more effective, achieve the appropriate sedation level more quickly, and provide a faster onset of sedation than midazolam in pediatric procedural sedation and analgesia. Propofol is preferred for imaging studies (computed tomography and magnetic resonance imaging) to reduce the occurrence of undesired motion artefacts. Although both drugs are safe to use for sedation before pediatric imaging procedures, propofol is preferred with appropriate preparation.

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Deep sedation with midazolam and propofol in children undergoing ambulatory magnetic resonance imaging of the brain

Abstract: The presented sedation technique for children undergoing ambulatory MRI of the brain is safe and adequate. This sedation regiment provides short induction time, fast recovery, stable cardiorespiratory conditions and rarely demans additional sedation.

Cited by 2 publications

References 8 publications

A comparison of the use of propofol alone and propofol with midazolam for pediatric magnetic resonance imaging sedation – a retrospective cohort study

A comparison of the use of propofol alone and propofol with midazolam for pediatric magnetic resonance imaging sedation – a retrospective cohort study

Comparison of Midazolam and Propofol for Sedation in Pediatric Diagnostic Imaging Studies

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