Deep-Sea Fungi: Diversity, Enzymes, and Bioactive Metabolites

Arifeen, Muhammad Zain Ul; Xue, Yarong; Liu, Changhong

doi:10.1007/978-3-030-19030-9_17

Cited by 4 publications

(5 citation statements)

References 80 publications

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“…Moreover, research on deep‐sea culturable fungi is useful for the development of new biotechnologies associated to their metabolic potential and unusual ecophysiological properties developed in unconventional environments. Marine fungal synthesis of new molecular structures for pharmaceutical use is widely recognized with a surge of recent research campaigns to discover new antibiotic, anti‐inflammatory, anti‐cancer and other bioactive compounds (Daletos et al ., 2018; Deshmukh et al ., 2018; Arifeen et al ., 2019; Wiese and Imhoff, 2019; Arifeen et al ., 2020). Metabolites isolated from deep‐sea organisms represent a small a fraction of the marine natural products described to date (>29,000; Skropeta and Wei, 2014; Carroll et al ., 2020) but this represents a promising environment for the discovery of new chemical entities.…”

Section: Introductionmentioning

confidence: 99%

Fungi populate deep‐sea coral gardens as well as marine sediments in the Irish Atlantic Ocean

Marchese

Garzoli

Young

et al. 2021

Environmental Microbiology

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Fungi populate deep Oceans in extreme habitats characterized by high hydrostatic pressure, low temperature and absence of sunlight. Marine fungi are potential major contributors to biogeochemical events, critical for marine communities and food web equilibrium under climate change conditions and a valuable source of novel extremozymes and small molecules. Despite their ecophysiological and biotechnological relevance, fungal deep-sea biodiversity has not yet been thoroughly characterized. In this study, we describe the culturable mycobiota associated with the deepest margin of the European Western Continental Shelf: sediments sampled at the Porcupine Bank and deep-water corals and sponges sampled in the Whittard Canyon. Eighty-seven strains were isolated, belonging to 43 taxa and mainly Ascomycota. Ten species and four genera were detected for the first time in the marine environment and a possible new species of Arachnomyces was isolated from sediments. The genera Cladosporium and Penicillium were the most frequent and detected on both substrates, followed by Candida and Emericellopsis. Our results showed two different fungal communities: sediment-associated taxa which were predominantly saprotrophic and animalassociated taxa which were predominantly symbiotic. This survey supports selective fungal biodiversity in the deep North Atlantic, encouraging further mycological studies on cold water coral gardens, often overexploited marine habitats.

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Section: Introductionmentioning

confidence: 99%

Fungi populate deep‐sea coral gardens as well as marine sediments in the Irish Atlantic Ocean

Marchese

Garzoli

Young

et al. 2021

Environmental Microbiology

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“…To prepare the ligand, we examined a wide range of natural bioactive chemicals derived from marine fungi that have previously been outlined in the literature [ 14 , 15 ]. Subsequently, 162 compounds were enrolled with ID numbers and chemical structures obtained from the PubChem database ( Supplementary Table 1 ).…”

Section: Methodsmentioning

confidence: 99%

Seawater fungi-derived compound screening to identify novel small molecules against dengue virus NS5 methyltransferase and NS2B/NS3 protease

Hasan

Mia

Munna

et al. 2022

Informatics in Medicine Unlocked

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“…[772][773][774] From other pigment classes with less prevalence, some alkaloids, such as 9-(1-hydroxyhexyl)-3-(2hydroxypropyl)-6a-methyl-9,9adihydrofuro[2,3-h] isoquinoline-6,8(2H,6aH)-dione (a Monascus pigment) isolated from M. purpureus Went has a suitable antibacterial effect on Grampositive bacteria. [166] Other examples of this class include chaetoviridide C, diazaquinomycin A, violacein, tambjamines, and prodiginines [180,209,775,776]. Several pigments with antibacterial, antiviral, antifungal, or antiprotozoal effects are mentioned in Tables 1-7.…”

Section: Anti-microbial and Anti-protozoal Activitymentioning

confidence: 99%

A Review of the Chemistry and Biological Activities of Natural Colorants, Dyes, and Pigments: Challenges, and Opportunities for Food, Cosmetics, and Pharmaceutical Application

Pasdaran

Zare

Hamedi

et al. 2023

Chemistry & Biodiversity

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Natural pigments are important sources for the screening of bioactive lead compounds. This article reviewed the chemistry and therapeutic potentials of over 570 colored molecules from plants, fungi, bacteria, insects, algae, and marine sources. Moreover, related biological activities, advanced extraction, and identification approaches were reviewed. A variety of biological activities, including cytotoxicity against cancer cells, antioxidant, anti‐inflammatory, wound healing, anti‐microbial, antiviral, and anti‐protozoal activities, have been reported for different pigments. Considering their structural backbone, they were classified as naphthoquinones, carotenoids, flavonoids, xanthones, anthocyanins, benzotropolones, alkaloids, terpenoids, isoprenoids, and non‐isoprenoids. Alkaloid pigments were mostly isolated from bacteria and marine sources, while flavonoids were mostly found in plants and mushrooms. Colored quinones and xanthones were mostly extracted from plants and fungi, while colored polyketides and terpenoids are often found in marine sources and fungi. Carotenoids are mostly distributed among bacteria, followed by fungi and plants. The pigments isolated from insects have different structures, but among them, carotenoids and quinone/xanthone are the most important. Considering good manufacturing practices, the current permitted natural colorants are: Carotenoids (canthaxanthin, β‐carotene, β‐apo‐8′‐carotenal, annatto, astaxanthin) and their sources, lycopene, anthocyanins, betanin, chlorophyllins, spirulina extract, carmine and cochineal extract, henna, riboflavin, pyrogallol, logwood extract, guaiazulene, turmeric, and soy leghemoglobin.

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Deep-Sea Fungi: Diversity, Enzymes, and Bioactive Metabolites

Cited by 4 publications

References 80 publications

Fungi populate deep‐sea coral gardens as well as marine sediments in the Irish Atlantic Ocean

Fungi populate deep‐sea coral gardens as well as marine sediments in the Irish Atlantic Ocean

Seawater fungi-derived compound screening to identify novel small molecules against dengue virus NS5 methyltransferase and NS2B/NS3 protease

A Review of the Chemistry and Biological Activities of Natural Colorants, Dyes, and Pigments: Challenges, and Opportunities for Food, Cosmetics, and Pharmaceutical Application

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