Deep rTMS for ADHD

Paz, Yaniv; Friedwald, K.; Levkovitz, Y.; Zangen, Abraham; Alyagon, Uri; Nitzan, Uri; Segev, Aviv; Maoz, Hagai; Koubi, May; Bloch, Yuval

doi:10.1016/j.brs.2017.01.224

Cited by 3 publications

(2 citation statements)

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“…Our results are in line with a pilot study ( 68 ) which evaluated the effect of tDCS and tRNS on ADHD symptoms. However, there is no consensus regarding the optimal treatment region in the brain for the treatment/management of ADHD symptoms ( 49 ); previous neuroscientific research seems to target the bilateral DLPFC ( 69 ), lDLPFC ( 4 ), rIFC ( 70 ), IFC-parieto-cerebellar networks or prefrontal striatal circuits ( 71 ). Future studies should determine the optimal TPS protocol and parameters to yield EF changes in the ADHD population.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of transcranial pulse stimulation in young adolescents with attention-deficit/hyperactivity disorder: a pilot, randomized, double-blind, sham-controlled trial

Cheung,

Yee,

Chau

et al. 2024

Front. Neurol.

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BackgroundThis is the first study to evaluate the efficacy and safety of transcranial pulse stimulation (TPS) for the treatment of attention-deficit/hyperactivity disorder (ADHD) among young adolescents in Hong Kong.MethodsThis double-blind, randomized, sham-controlled trial included a TPS group and a sham TPS group, encompassing a total of 30 subjects aged 12–17 years who were diagnosed with ADHD. Baseline measurements SNAP-IV, ADHD RS-IV, CGI and executive functions (Stroop tests, Digit Span) and post-TPS evaluation were collected. Both groups were assessed at baseline, immediately after intervention, and at 1-month and 3-month follow-ups. Repeated-measures ANOVAs were used to analyze data.ResultsThe TPS group exhibited a 30% reduction in the mean SNAP-IV score at postintervention that was maintained at 1- and 3-month follow-ups.ConclusionTPS is an effective and safe adjunct treatment for the clinical management of ADHD.Clinical trial registrationClinicalTrials.Gov, identifier NCT05422274.

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Section: Discussionmentioning

confidence: 99%

Efficacy and safety of transcranial pulse stimulation in young adolescents with attention-deficit/hyperactivity disorder: a pilot, randomized, double-blind, sham-controlled trial

Cheung,

Yee,

Chau

et al. 2024

Front. Neurol.

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“…Transcranial magnetic stimulation (TMS) has a limited but growing body of evidence for its efficacy in both ADHD (46–48) and OCD (49, 50) Combined with its relative safety, TMS may be a viable option for treating co-morbid ADHD and OCD, pending further clinical trials. Additionally, where symptoms remain resistant to both pharmacological and psychological approaches and OCD symptoms significantly disrupt daily functioning, intensive residential treatment may be considered if available (51).…”

Section: Treatment Implications For Co-morbid Ocd–adhdmentioning

confidence: 99%

Co-Morbid Obsessive–Compulsive Disorder and Attention Deficit Hyperactivity Disorder: Neurobiological Commonalities and Treatment Implications

et al. 2019

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Evaluating the efficacy and safety of transcranial pulse stimulation on adolescents with attention deficit hyperactivity disorder: Study protocol of a pilot randomized, double-blind, sham-controlled trial

Cheung

Chau²,

Fong³

et al. 2023

Front. Neurol.

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BackgroundTraditional treatment alone might not effectively control the severity of attention deficit hyperactivity disorder (ADHD) symptoms. Transcranial pulse stimulation (TPS) is a non-invasive brain stimulation (NIBS) technology used on older adults with mild neurocognitive disorders and adults with major depressive disorder. However, there has been no study conducted on young adolescents with ADHD. This will be the first nationwide study evaluating the efficacy and safety of TPS in the treatment of ADHD among young adolescents in Hong Kong.MethodsThis study proposes a double-blinded, randomized, sham-controlled trial including TPS as an intervention group and a sham TPS group. Both groups will be measured at baseline (T1), immediately after the intervention (T2), and at the 1-month (T3) and 3-month follow-ups (T4).RecruitmentA total of 30 subjects aged between 12 and 17 years, diagnosed with attention deficit hyperactivity disorder (ADHD), will be recruited in this study. All subjects will be computer randomized into either the intervention group or the sham TPS group on a 1:1 ratio.InterventionAll subjects in each group will have to undertake functional MRI (fMRI) before and after six 30-min TPS sessions, which will be completed in 2 weeks' time.OutcomesBaseline measurements and post-TPS evaluation of the ADHD symptoms and executive functions will also be conducted on all participants. The 1- and 3-month follow-up periods will be used to assess the long-term sustainability of the TPS intervention. For statistical analysis, ANOVA with repeated measures will be used to analyze data. Missing data were managed by multiple imputations. The level of significance will be set to p < 0.05.Significance of the studyResults emerging from this study will generate new knowledge to ascertain whether TPS can be used as a top-on treatment for ADHD.Clinical trial registrationclinicaltrails.gov, identifier: NCT05422274.

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Deep rTMS for ADHD

Cited by 3 publications

References 0 publications

Efficacy and safety of transcranial pulse stimulation in young adolescents with attention-deficit/hyperactivity disorder: a pilot, randomized, double-blind, sham-controlled trial

Efficacy and safety of transcranial pulse stimulation in young adolescents with attention-deficit/hyperactivity disorder: a pilot, randomized, double-blind, sham-controlled trial

Co-Morbid Obsessive–Compulsive Disorder and Attention Deficit Hyperactivity Disorder: Neurobiological Commonalities and Treatment Implications

Evaluating the efficacy and safety of transcranial pulse stimulation on adolescents with attention deficit hyperactivity disorder: Study protocol of a pilot randomized, double-blind, sham-controlled trial

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