Deep Networks and Continuous Distributed Representation of Protein Sequences for Protein Quality Assessment

Aplicaciones de las redes neuronales y el deep learning a la ingeniería biomédica

“…La predicción de la estructura de una proteína es crucial para determinar su función y aplicación, por lo tanto, dentro de la proteómica y la epigenómica, se ha investigado en aplicaciones que permiten la predicción de los ángulos de la columna vertebral de la proteína (que permite obtener información sobre la estructura de la proteína) [36][37][38], la predicción de la estructura secundaria y terciaria de la proteína [39][40][41][42][43][44][45][46][47], la evaluación de la calidad de la proteína [48][49][50], y la predicción de las regiones de desórdenes (trastornos) en la estructura de la proteína [51][52].…”

Deep Learning in the Biomedical Applications: Recent and Future Status

“…Backbone angles prediction: Prediction of the protein backbone torsion angles (Psi and Phi) can provide important information for protein structure prediction and sequence alignment[133,[135][136][137].• Protein secondary structure prediction: Prediction of the secondary structure of the protein is an important step for the prediction of the three-dimensional structure and concentrates a large part of the scientific publications[134,[138][139][140][141][142][143][144][145][146].•Protein tertiary structure (3D) prediction: Protein tertiary structure deals with the three-dimensional protein structure and gives how the regional structures are put together in space[147][148][149][150][151][152].•Protein quality assessment (QA): In the process of protein three-dimensional structure prediction, assessing the quality of the generated models accurately is crucial. The protein structure quality assessment (QA) is an essential component in protein structure prediction and analysis[153][154][155].•Protein loop modeling and disorder prediction: Biology and medicine have a long-standing interest in computational structure prediction and modeling of proteins. There are often missing regions or regions that need to be remodeled in protein structures.…”