“…Sudden unexpected death (2) and Cardiovascular complications of hypopituitarism have been described previously but reports of lethal cardiac arrhythmia are very rare (3-5) as are electrocardiographic changes in hypopituitarism (6, 7) the electrocardiographic changes that are considered to be associated with hypopituitarism are giant T inversion, QT prolongation and ST changes. The exact cause of electrocardiographic changes in such cases is not defined but hypoglycemia, catecholamine surge secondary to hypoglycemia and hypomagnesemia, or decrease ACTH level (2) are considered as possible cause, such changes mimics ischemia and intracranial pathology but in our patient coronary disease was ruled out by coronary angiography, other possible causes of QT prolongation such as genetic or drug induced may be considered in our case but history was negative for use of such medications and as seen in (Figure 1) the ECG in 29.4.2008 QT interval was normal before possible aggravation of endocrine condition which may have been triggered by discontinuation of drugs or emotional stress before onset of ventricular arrhythmia .…”