Deep neck abscess as the predominant initial presentation of carcinoma of unknown primary: A case report

Chen, Wei‐Ting; Lee, Jui‐Wen; Hsieh, Kun‐Wei; Chen, Rongfeng

doi:10.3892/ol.2014.1835

Cited by 4 publications

(6 citation statements)

References 10 publications

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“…In evaluating human patients, a deep neck abscess should be considered a differential diagnosis if severe, acute pain is reported, upper respiratory tract infection, trauma associated with the head or mouth, respiratory distress, dysphagia, asymmetry of the neck, lymphadenopathy, cranial nerve involvement, pyrexia, tachypnoea, or immunosuppression [ 7 ]. In human medicine, lymph node abscesses have been associated with nasopharyngeal carcinoma, Hodgkin's lymphoma, B-cell lymphoma, squamous cell carcinoma, and carcinoma of unknown primary [ 8 , 11 – 13 ]. Both dogs presented to the teaching hospital for lethargy, hyporexia to anorexia, and stridor while at rest.…”

Section: Discussionmentioning

confidence: 99%

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Lymph Node Abscessation Secondary to Neoplasia in Two Dogs

Lumbrezer-Johnson

Hostnik

et al. 2022

Case Reports in Veterinary Medicine

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A 5-year-old male neutered mixed breed dog and an 8-year-old female spayed golden retriever presented for cervical swelling which was later diagnosed as abscessation of the retropharyngeal lymph node with a malignant round cell tumor and carcinoma with multifocal squamous differentiation, respectively. In veterinary medicine, there is limited published information regarding abscessation of lymph nodes secondary to a neoplastic process. While more common in humans, there are only limited case reports available. Advanced imaging (computed tomography), cytology, surgical excision, and histopathology lead to the final diagnosis. Both dogs underwent surgical extirpation of the lymph nodes and adjuvant chemotherapy protocols. Six weeks postsurgical excision, dog one was euthanized due to quality-of-life concerns. The second dog successfully completed 18 treatments of radiation therapy and was still alive at 388 days postsurgical excision. At the time of manuscript submission, the second dog was doing well clinically.

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Section: Discussionmentioning

confidence: 99%

“…In humans, diagnosis of neoplasia can be complicated by the presence of a coexisting infection [ 8 ]. Culture results of 90% of retropharyngeal abscesses in people had polymicrobial infections [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Lymph Node Abscessation Secondary to Neoplasia in Two Dogs

Lumbrezer-Johnson

Hostnik

et al. 2022

Case Reports in Veterinary Medicine

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“…A component of tall cell PTC which is aggressive in behavior may contribute to the large size of tumor and lymph nodes [ 8 ]. Another potential mechanism is the infected ulcer of the primary tumor which drains to the lymph node and forms an abscess [ 9 ]. The source of infection may arise from the mandibular teeth, tonsils, parotid gland, middle ear, or sinuses.…”

Section: Discussionmentioning

confidence: 99%

“…However, cytological examination of the cystic lesions of malignancy might yield a false-negative result because of the dilutional effect of cystic fluid. Routine pathological examination of the abscess tissue is recommended in all cases with DNI, especially in those over 40 years of age [ 2 , 7 , 9 , 12 ]. If the neck swelling diminishes, repeated FNAB, endoscopic examination of the upper aerodigestive tract, or imaging study should be considered.…”

Section: Discussionmentioning

confidence: 99%

Deep Neck Infection: Atypical Presentation of Papillary Thyroid Cancer

Mahattanapreut

Aroonroch

Chintrakarn

et al. 2021

Case Reports in Otolaryngology

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Deep neck infection is defined as an infectious process in the potential spaces and fascial plane of the neck which may result in a fatal complication. Prompt drainage and broad-spectrum antibiotics are the mainstays of treatment. Deep neck infection as the initial presentation of primary head and neck cancer is not common. Nevertheless, head and neck squamous cell carcinoma is the most common primary head and neck cancer, which could present with cervical metastasis and subsequently becomes infected. Papillary thyroid cancer has a naturally indolent course, and most patients present with a thyroid nodule. However, deep neck infection could be an uncommon presentation of papillary thyroid cancer which may obscure the diagnosis of underlying malignancy. This case report aims to present a rare presentation of papillary thyroid cancer which needs meticulous evaluation. Moreover, the pathological examination should be performed in all cases of deep neck infection for early detection and management of underlying papillary thyroid cancer.

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“…Tumour necrosis, owing to poor vascular supply, makes the centre of large malignant lesions susceptible to infection 1…”

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confidence: 99%