Deep metagenomic characterization of gut microbial community and function in preeclampsia

Lv, Lijuan; Li, Shenghui; Wen, Jiying; Wang, Guang-Yang; Li, Hui; He, Tian-Wen; Lv, Qingbo; Xiao, Manchun; Hong-li, Duan; Chen, Min-Chai; Yi, Zhou-Ting; Yan, Qiulong; Yin, Aihua

doi:10.3389/fcimb.2022.933523

Cited by 13 publications

(11 citation statements)

References 78 publications

(119 reference statements)

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“…Among the biomarkers of preeclampsia, a significant downregulation of the KEGG pathways of folate metabolism, the metabolism of cofactors and other vitamins, pyridoxal-P biosynthesis, riboflavin metabolism, and cobalamin biosynthesis was found. Conversely, the microbiota resulted in an enrichment of the species belonging to the genera Blautia, Pauljensenia, Ruminococcus, and Collinsella [153].…”

Section: Discussionmentioning

confidence: 99%

Factors Affecting Gut Microbiota of Puppies from Birth to Weaning

Balouei

Stefanon

Sgorlon

et al. 2023

Animals

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The review described the most important factors affecting the development of the intestinal microbiota in puppies from birth to weaning. The health and well-being of the microbiome in puppies is influenced by the type of parturition, the maternal microbiota, and the diet of the mother, directly or indirectly. The isolation of bacteria in dogs from the placenta, fetal fluids, and fetuses suggests that colonization could occur before birth, although this is still a matter of debate. Accordingly, newborn puppies could harbor bacteria that could be of maternal origin and that could influence microbial colonization later in life. However, the long-term impacts on health and the clinical significance of this transfer is not yet clear and needs to be investigated. The same maternal bacteria were found in puppies that were born vaginally and in those delivered via cesarean section. Potentially, the relationship between the type of parturition and the colonization of the microbiome will influence the occurrence of diseases, since it can modulate the gut microbiome during early life. In addition, puppies’ gut microbiota becomes progressively more similar to adult dogs at weaning, as a consequence of the transition from milk to solid food that works together with behavioral factors. A number of researchers have investigated the effects of diet on the gut microbiota of dogs, revealing that dietary interference may affect the microbial composition and activity through the production of short-chain fatty acids and vitamins. These compounds play a fundamental role during the development of the fetus and the initial growth of the puppy. The composition of the diet fed during pregnancy to the bitches is also an important factor to consider for the health of newborns. As far as it is known, the effects of the type of parturition, the maternal microbiota, and the diet on the microbial colonization and the long-term health of the dogs deserve further studies. Definitely, longitudinal studies with a larger number of dogs will be required to assess a causal link between microbiome composition in puppies and diseases in adult dogs.

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Section: Discussionmentioning

confidence: 99%

Factors Affecting Gut Microbiota of Puppies from Birth to Weaning

Balouei

Stefanon

Sgorlon

et al. 2023

Animals

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“…Once the flora is out of balance, the balance will be destroyed, and inflammatory factors will increase, which will damage vascular endothelial cells, and then affect the stability of the blood system. Bacteroides , Bifidobacterium, and Lachnospiraceae have been proven to be related to the inflammatory-immune response mediated by intestinal flora ( Miao et al, 2021 ; Huang et al, 2022 ; Lv et al, 2022 ). In addition, dyslipidemia and renal dysfunction are also important factors affecting the occurrence and development of preeclampsia.…”

Section: Discussionmentioning

confidence: 99%

Clinical study on the difference in intestinal microecology between patients with preeclampsia and pregnant women at different stages of pregnancy

Xie,

Zhang,

Peng

et al. 2024

Acta Biochim. Pol.

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Objective: To explore the difference in intestinal microecology between patients with preeclampsia and pregnant women at different stages of pregnancy.Methods: From January 2020 to January 2022, clinical data, including blood routine, lipid profile, and renal function indicators, were gathered from a cohort consisting of 5 cases of preeclampsia and 34 cases of non-preeclampsia. The non-preeclampsia group was further categorized into 6 cases in the First trimester, 13 cases in the Second trimester, and 15 cases in the Third trimester. The data collection took place at the Obstetrics Department of the Maternal and Child Health Hospital of Hubei Province. Additionally, fecal samples were obtained from each subject for 16S rDNA gene sequencing and subsequent analysis. The clinical data and composition characteristics of the gut microbiota in each group were analyzed, and the correlation between gut microbiota and clinical data was analyzed by the Spearman correlation analysis method.Results: In comparison to pregnant women without preeclampsia, preeclampsia patients exhibited a statistically significant elevation in blood routine parameters (WBC, N, L, and PLT count), a rise in lipid-related indicators (TC, TG, and LDL-C levels), a reduction in HDL-C levels, and an increase in renal function-related indicators (Cr, BUN, UA and Pro levels). Compared with non-preeclampsia pregnant women, preeclampsia women exhibited an augmented diversity of gut microbiota. Differences in gut microbiota composition between the two groups were observed at the gate and genus levels. Moreover, there are significant differences in the composition of gut microbiota between the preeclampsia group and the third-trimester group in terms of genus and species, and this difference is mainly caused by Prevotella and s_ Bacteroides_ Uniformis and Ruminococcus_ bromii. In addition, actinobacteria, bifidobacterium at the genus level, and Ruminococcus_bromii at the species level are positively correlated with clinically relevant indicators (excluding HDL-C).Conclusion: There are significant differences in gut microbiota between preeclampsia pregnant women and late pregnancy pregnant without preeclampsia, including Prevotella and Bacteroides_ Uniformis, and Ruminococcus_ bromii. In addition, these differential bacteria are correlated with most clinical indicators. However, additional comprehensive analysis is required to ascertain the functional correlation between these bacteria and clinical indicators.

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“…We also found that IMC treatment decreased the genus Phocacecola . It was recently shown that Phocaeicola might be related to preeclampsia occurrence [ 26 ], while currently there is a lack of information regarding its link with hypertension.…”

Section: Discussionmentioning

confidence: 99%

Iodomethylcholine Inhibits Trimethylamine-N-Oxide Production and Averts Maternal Chronic Kidney Disease-Programmed Offspring Hypertension

Tain

Chang-Chien

Lin

et al. 2023

IJMS

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Chronic kidney disease (CKD) affects 10% of the global population, including pregnant women. Adverse maternal conditions determine the developmental programming of many diseases later in life. We previously demonstrated that adult rat offspring born to dams with CKD developed hypertension and renal hypertrophy. Trimethylamine-N-oxide (TMAO), a uremic toxin derived from the gut microbiota, has been linked to hypertension. This study assesses the effects of TMAO inhibition by iodomethylcholine (IMC) treatment on offspring hypertension programmed by maternal CKD. Female rats were fed either a control or a 0.5% adenine diet before conception, with or without IMC treatment during pregnancy and lactation. Maternal IMC treatment averted maternal CKD-primed offspring hypertension and renal hypertrophy in 12-week-old offspring. Offspring hypertension is associated with increases in the plasma TMAO concentration and oxidative stress and shifts in gut microbiota. The beneficial effects of IMC are related to a reduction in TMAO; increases in genera Acetatifactor, Bifidobacterium, and Eubacterium; and decreases in genera Phocacecola and Bacteroides. Our findings afford insights into the targeting of the gut microbiota to deplete TMAO production, with therapeutic potential for the prevention of offspring hypertension programmed by maternal CKD, although these results still need further clinical translation.

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Deep metagenomic characterization of gut microbial community and function in preeclampsia

Cited by 13 publications

References 78 publications

Factors Affecting Gut Microbiota of Puppies from Birth to Weaning

Factors Affecting Gut Microbiota of Puppies from Birth to Weaning

Clinical study on the difference in intestinal microecology between patients with preeclampsia and pregnant women at different stages of pregnancy

Iodomethylcholine Inhibits Trimethylamine-N-Oxide Production and Averts Maternal Chronic Kidney Disease-Programmed Offspring Hypertension

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