Deep‐Level Defect Enhanced Photothermal Performance of Bismuth Sulfide–Gold Heterojunction Nanorods for Photothermal Therapy of Cancer Guided by Computed Tomography Imaging

Cheng, Yan; Chang, Yun; Yu, Feng; Jian, Hui; Tang, Zhaohui; Zhang, Haiyuan

doi:10.1002/anie.201710399

Cited by 271 publications

(189 citation statements)

References 29 publications

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“…The synthesis of gold nanorods (AuNRs) is of considerable interest owing to their unique optical properties, which can be used for imaging, surface‐enhanced Raman spectroscopy (SERS), diagnostics, sensing, and biological applications . Murphy et al .…”

Section: Introductionmentioning

confidence: 99%

“…The synthesis of gold nanorods (AuNRs)i so fc onsiderable interest owing to their unique optical properties,w hich can be used for imaging, [1][2][3][4][5][6][7][8] surface-enhanced Raman spectroscopy (SERS), [9][10][11][12] diagnostics, [13][14][15] sensing, [16,17] and biologicala pplications. [18][19][20][21][22][23][24] Murphy et al [25] first reported the seed-mediated chemicals ynthesis of AuNRs. This method produces pentahedrally twinned AuNRsw ith an aspectr atio up to 25.…”

Section: Introductionmentioning

confidence: 99%

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Gram‐Scale Synthesis of Isolated Monodisperse Gold Nanorods

Khanal

Zubarev

2018

Chemistry A European J

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Although gold nanorods (AuNRs) have strong potential applications in nanotechnology, plasmonics, and sensing, the scale‐up synthesis of isolated AuNRs in gram quantities remains a challenge. Nearly all previously reported methods produce aqueous solutions of cetyltrimethylammonium bromide (CTAB)‐coated AuNRs in milligram quantities with yields of approximately 20–30 % in terms of AuI to Au0 conversion. In addition, it is difficult to remove the CTAB bilayer from the surface of AuNRs and yet make them soluble and functionalized for further processing and chemical modification. This report describes the synthesis of monodisperse functionalized AuNRs (standard deviation, σ≈5 %) in gram quantities. Our approach involved increasing the concentration of HAuCl4⋅3 H2O in the growth solution to produce larger quantities of starting AuNRs and further reducing the remaining AuI ions onto the surface of AuNRs. The slow and controlled addition of ascorbic acid as a reducing agent continued the conversion of AuI into Au0 (through a disproportionation reaction) onto the surface of the nanorods, which maintained their uniform morphology without creating any unwanted impurities of various shapes. In addition, this approach significantly narrowed the size distribution owing to continuous growth of the partially grown AuNRs during the initial stage of the synthesis. To isolate a 1 g quantity of the AuNRs and to make them functionalized for further chemical reactions, a ligand‐exchange approach was utilized, in which the CTAB surfactant was replaced with 4‐mercaptophenol. The thiol group from 4‐mercaptophenol formed a covalent bond with the surface of the AuNRs, leaving free functional OH groups available for further chemical coupling reactions. For the ligand‐exchange process, a concentrated solution of 4‐mercaptophenol in tetrahydrofuran solution was introduced into the AuNRs solution. Pure AuNRs functionalized with 4‐mercaptophenol were isolated by dispersion and rinsing with an excess amount of THF, followed by centrifugation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gram‐Scale Synthesis of Isolated Monodisperse Gold Nanorods

Khanal

Zubarev

2018

Chemistry A European J

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“…Building on this knowledge, we incorporated Au nanodots into Bi 2 S 3 NRs to form Bi 2 S 3 ‐Au heterojunction NRs, which showed significantly enhanced photothermal performance under NIR laser irradiation (from 33.58 % of Bi 2 S 3 NRs to 51.06 % of Bi 2 S 3 ‐Au NRs). This enhancement is probably ascribed to increased chance of electron‐hole nonradiative recombination because more Bi S defects can be formed due to Au‐mediated S replacement with Bi atoms, and simultaneously more electrons can reach Bi S defects through Au Fermi level (Figure B) . Other methods have also been used to improve the photothermal conversion efficiency of Bi 2 S 3 NPs.…”

Section: Bi‐based Nms Used For Cancer Therapymentioning

confidence: 99%

“…This enhancement is probably ascribed to increased chance of electron-hole nonradiative recombination because more Bi S defects can be formed due to Au-mediated Sr eplacement with Bi atoms, and simultaneously more electrons can reach Bi S defects through Au Fermi level ( Figure 7B). [80] Other methods have also been used to improvet he photothermal conversion efficiency of Bi 2 S 3 NPs. Reducing the sizes of Bi 2 S 3 NPsi ss till an effective strategy to enhancet heir photothermal performance thought here is no systematic research on the effect of surface and volumer atio.…”

Section: Phototherapymentioning

confidence: 99%

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Novel Bismuth‐Based Nanomaterials Used for Cancer Diagnosis and Therapy

Cheng

Zhang

2018

Chemistry A European J

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Theranostic nanomaterials (NMs) have gained increasing attention for their simultaneous performance of diagnosis and therapy. Bi-based NMs hold great potential as theranostic platforms based on their X-ray sensitive capability, near-infrared driven semiconductor properties, and distinctive structures, which facilitate the computed tomography (CT) imaging, photoacoustic (PA) imaging, radiation therapy, and phototherapy. The sophisticated design in composition, structure, and surface fabrication of Bi-based NMs can endow these NMs with more modalities in cancer diagnosis and therapy. In this Minireview, we focus on the recent advances in Bi-based theranostic NMs. A series of unique structures and functions as well as the underlying property-activity relationship of Bi-based NMs are showcased to highlight their promising imaging and therapeutic performance. At the end, we propose some challenges for the design and preparation of Bi-based NMs to improve their cancer diagnostic and therapeutic performance.

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Ultrasound‐Activated Oxygen and ROS Generation Nanosystem Systematically Modulates Tumor Microenvironment and Sensitizes Sonodynamic Therapy for Hypoxic Solid Tumors

Zhu

et al. 2019

Adv Funct Materials

182

119

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Sonodynamic therapy (SDT) is noninvasive and possesses high bodypenetration depth, showing great potential for the treatment of deep-seated solid tumors. The efficacy of SDT, however, is limited by widespread hypoxia in solid tumors. Given this, an ultrasound-activated nanosystem is developed by integrating ferrate(VI) and protoporphyrin IX into biodegradable hollow mesoporous organosilica nanoplatforms, followed by assembling a phasechange material of lauric acid. The ferrate(VI) effectively reacts with water as well as overexpressed hydrogen peroxide and glutathione (GSH) in tumor cells, leading to tumor-microenvironment-independent oxygen production and in situ GSH depletion in tumors. More importantly, significant reactive oxygen species (ROS) overproduction is simultaneously achieved by protoporphyrin-augmented SDT and intracellular Fenton chemistry. Furthermore, the mild hyperthermia induced by ultrasound can trigger the phase change of lauric acid, achieving ultrasound-responsive control over the release of oxygen and ROS, and the depletion of GSH. The simultaneous oxygen generation, in situ GSH depletion, and ROS overproduction play a synergetic role in sensitizing SDT toward hypoxic solid tumors, which is verified by the remarkable improvement of hypoxic environments and more significant growth inhibition of SDT against osteosarcoma both in vitro and in vivo, showing promising application in hypoxic solid tumor treatment.

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Deep‐Level Defect Enhanced Photothermal Performance of Bismuth Sulfide–Gold Heterojunction Nanorods for Photothermal Therapy of Cancer Guided by Computed Tomography Imaging

Cited by 271 publications

References 29 publications

Gram‐Scale Synthesis of Isolated Monodisperse Gold Nanorods

Gram‐Scale Synthesis of Isolated Monodisperse Gold Nanorods

Novel Bismuth‐Based Nanomaterials Used for Cancer Diagnosis and Therapy

Ultrasound‐Activated Oxygen and ROS Generation Nanosystem Systematically Modulates Tumor Microenvironment and Sensitizes Sonodynamic Therapy for Hypoxic Solid Tumors

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