Deep Learning to Predict the Effect of Drugs in Patients With Lymphoma Based on Cell Line Data

Abstract

Introduction: Entra-nodal NK/T cell lymphoma (NKTCL) is an aggressive malignant lymphoma, with a prevalence of East Asia.Nowadays, despite of the promising improvement, there remains an urgent need of novel agent to improve the dismal prognosis of relapse and refractory patients.Bendamustine combines the properties of purine analogue and alkylating agent, which has been successfully used for B lymphoid neoplasms. However, its use in T cell lymphoma is limited, especially in NKTCL. Herein, we describe for the first time the potential efficacy of bendamustine in NKTCL.Methods and materials: NKTCL cell lines (NKYS, KHYG-1, NKL) were obtained from ExPASy. Bendamustine, chloroquine, concanamycin A and bafilomycin were purchased from Selleckchem. Cell proliferation