Deep Learning Prediction of Glycopeptide Tandem Mass Spectra Powers Glycoproteomics
Yu Zong,
Yuxin Wang,
Xipeng Qiu
et al.
Abstract:Protein glycosylation plays a significant role in numerous physiological and pathological cellular functions. Glycoproteomics based on liquid chromatography-tandem mass spectrometry (LC-MS/MS) studies the protein glycosylation on a proteome-wide scale to get combinational information on glycosylation site, glycosylation level and glycan structure. However, the current sequence searching-based methods for glycoproteomics often fall short in glycan structure determination due to the limited occurrence of structu… Show more
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