Abstract:Recent computational advances in the accurate prediction of protein three-dimensional (3D) structures from amino acid sequences now present a unique opportunity to decipher the interrelationships between proteins. This task entailsbut is not equivalent toa problem of 3D structure comparison and classification. Historically, protein domain classification has been a largely manual and subjective activity, relying upon various heuristics. Databases such as CATH represent significant steps towards a more systemati… Show more
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