Deep learning classification of early normal-tension glaucoma and glaucoma suspect eyes using Bruch’s membrane opening-based disc photography

Abstract

PurposeWe aimed to investigate the performance of a deep learning model to discriminate early normal-tension glaucoma (NTG) from glaucoma suspect (GS) eyes using Bruch’s membrane opening (BMO)-based optic disc photography.Methods501 subjects in total were included in this cross-sectional study, including 255 GS eyes and 246 eyes of early NTG patients. BMO-based optic disc photography (BMO overview) was obtained from spectral-domain optical coherence tomography (OCT). The convolutional neural networks (CNN) model built from scratch was used to classify between early NTG and GS. For diagnostic performances of the model, the accuracy and the area under the curve (AUC) of the receiver operating characteristic curve (ROC) were evaluated in the test set.ResultsThe baseline demographics were age, 48.01 ± 13.03 years in GS, 54.48 ± 11.28 years in NTG (p = 0.000); mean deviation, −0.73 ± 2.10 dB in GS, −2.80 ± 2.40 dB in NTG (p = 0.000); and intraocular pressure, 14.92 ± 2.62 mmHg in GS, 14.79 ± 2.61 mmHg in NTG (p = 0.624). Our CNN model showed the mean AUC of 0.94 (0.83–1.00) and the mean accuracy of 0.91 (0.82–0.98) with 10-fold cross validation for discriminating between early NTG and GS.ConclusionThe performance of the CNN model using BMO-based optic disc photography was considerably good in classifying early NTG from GS. This new disc photography of BMO overview can aid in the diagnosis of early glaucoma.

Automated Classification of Physiologic, Glaucomatous, and Glaucoma-Suspected Optic Discs Using Machine Learning

“…Seo and Cho [ 25 ] were able to discriminate between 229 eyes from glaucoma suspects and 168 from patients with normal tension glaucoma (NTG) with a CNN model using BMO-MRW and RNFL, achieving an AUC of 0.96. In a more recent work by the same research group, they achieved an AUC of 0.94, discriminating between 255 glaucoma suspects and 245 patients with NTG with a CNN model using BMO-based optic disc photography [ 46 ].…”