Deep learning‐based photodamage reduction on harmonic generation microscope at low‐level optical power
Yi‐Jiun Shen,
En‐Yu Liao,
Tsung‐Ming Tai
et al.
Abstract:The trade‐off between high‐quality images and cellular health in optical bioimaging is a crucial problem. We demonstrated a deep‐learning‐based power‐enhancement (PE) model in a harmonic generation microscope (HGM), including second harmonic generation (SHG) and third harmonic generation (THG). Our model can predict high‐power HGM images from low‐power images, greatly reducing the risk of phototoxicity and photodamage. Furthermore, the PE model trained only on normal skin data can also be used to predict abnor… Show more
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