Deep learning-based Helicobacter pylori detection for histopathology: A diagnostic study

Abstract

Aims: Deep learning (DL), a sub-area of artificial intelligence, has demonstrated great promise at automating diagnostic tasks in pathology, yet its translation into clinical settings has been slow. Few studies have examined its impact on pathologist performance, when embedded into clinical workflows. The identification of H. pylori on H&E stain is a tedious, imprecise task which might benefit from DL assistance. Here, we developed a DL assistant for diagnosing H. pylori in gastric biopsies and tested its impact on pathologist diagnostic accuracy and turnaround time. Methods and results: H&E-stained whole-slide images (WSI) of 303 gastric biopsies with ground truth confirmation by immunohistochemistry formed the study dataset; 47 and 126 WSI were respectively used to train and optimize our DL assistant to detect H. pylori, and 130 were used in a clinical experiment in which 3 experienced GI pathologists reviewed the same test set with and without assistance. On the test set, the assistant achieved high performance, with a WSI-level area-under-the-receiver-operating-characteristic curve (AUROC) of 0.965 (95% CI 0.934-0.987). On H. pylori-positive cases, assisted diagnoses were faster (β, the fixed effect size for assistance= -0.557, p=0.003) and much more accurate (OR=13.37, p<0.001) than unassisted diagnoses. However, assistance increased diagnostic uncertainty on H. pylori-negative cases, resulting in an overall decrease in assisted accuracy (OR=0.435, p=0.016) and negligible impact on overall turnaround time (β for assistance=0.010, p=0.860). Conclusions: DL can assist pathologists with H. pylori diagnosis, but its integration into clinical workflows requires optimization to mitigate diagnostic uncertainty as a potential consequence of assistance.

Potentials of AI in medical image analysis in Gastroenterology and Hepatology

“…The DL algorithm output continuous scores for quantifying the extent of each feature and the quantitative comparison with human pathologists achieved very good agreement, such as steatosis. Zhou et al 29 employed DL approach for Helicobacter pylori detection from histopathology images. They found assisted diagnosis with DL was faster and much more accurate than that without on positive cases.…”